Organic chemistry
Hemant Chavan; Datta Survase; Sakharam Dongare; Vasant Helavi; Shreeram Ganapure
Volume 5, Issue 1, pp. 1-120, Serial No. 14 , January 2017, , Pages 105-114
Abstract
Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions ...
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Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions preceeded within a short period of time with excellent purity. All of the synthesized compounds were identified by IR, 1H NMR, 13C NMR and mass spectroscopy. Quantitative yields, inexpensive and environmentally friendly solvent system and simple work-up procedure are the attractive features of the present method. It is thus enviro-economic method without producing hazardous wastes. The formed pyranopyrazoles might find to possess important biological and pharmaceutical applications.
Organic chemistry
Hemant Vilas Chavan; Dnyaneshwar M. Sirsat; Yoginath B. Mule
Volume 4, Issue 4, pp. 359-490, Serial No. 13 , October 2016, , Pages 373-388
Abstract
An environmentally benign and clean synthesis of aryl-hydrazones by reacting variety of carbonyl compounds with thiosemicarbazide, semicarbazide, aminoguanidine, and phenyl hydrazine has been achieved using aqueous extract of Acacia concinna pods as a natural surfactant type catalyst. We found that the ...
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An environmentally benign and clean synthesis of aryl-hydrazones by reacting variety of carbonyl compounds with thiosemicarbazide, semicarbazide, aminoguanidine, and phenyl hydrazine has been achieved using aqueous extract of Acacia concinna pods as a natural surfactant type catalyst. We found that the aqueous extract of Acacia concinna pods could be effectively used for the synthesis of aryl-hydrazones. This efficient process proceeds smoothly in aqueous medium at room temperature within a very short period of time. All the products were obtained by simple filtration. The low cost, easy availability of the catalyst and simple reaction conditions are the notable features of the present method.