Organic chemistry
Nader Noroozi Pesyan; Ali Gharib; Azam Monfared
Abstract
A convenient route for cyanation and bromination of some electron-rich aromatics (anisole, 1,3-dimethoxybenzene, 1,4-dimethoxybenzene, 1,3,5-trimethoxybenzene and β-naphthol) by BrCN in the presence of aluminum trichloride (AlCl3), as catalyst, by grinding method under solvent-free conditions at ...
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A convenient route for cyanation and bromination of some electron-rich aromatics (anisole, 1,3-dimethoxybenzene, 1,4-dimethoxybenzene, 1,3,5-trimethoxybenzene and β-naphthol) by BrCN in the presence of aluminum trichloride (AlCl3), as catalyst, by grinding method under solvent-free conditions at room temperature to 60 °C was described in good yield. The structures of all obtained products were characterized by FT-IR, 1H NMR, 13C NMR, and Mass spectrometry techniques. Anisole and 4-cyanobenzonitrile afforded both cyanated and brominated products. 1,3-Dimethoxybenzene yielded to two types of the cyanated products. 1,4-Dimethoxybenzene has done some unusual coupling reactions via new Beckmann-type rearrangement. No bromination of 1,4-dimethoxybenzene was observed under the same conditions. 1,3,5-Trimethoxybenzene and β-naphthol obtained both cyanated and brominated products which were analyzed by HPLC technique.
Organic chemistry
Mohammad Reza Poor Heravi; Aazam Monfared Monfared; Masoumeh Ahmadi
Volume 4, Issue 4, pp. 359-490, Serial No. 13 , October 2016, , Pages 433-448
Abstract
A facile and efficient synthesis of bis(indolyl)methanes derivatives (3a-u) was reported via a condensation reaction of aldehydes and indole in the presence of by silica-supported-3-(triethoxysilyl) propane-1-ammonium chloride catalysis under solvent free conditions. We studied the reaction in different ...
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A facile and efficient synthesis of bis(indolyl)methanes derivatives (3a-u) was reported via a condensation reaction of aldehydes and indole in the presence of by silica-supported-3-(triethoxysilyl) propane-1-ammonium chloride catalysis under solvent free conditions. We studied the reaction in different conditions and optimized. The use of just 0.02 g of (silica gel-ammonium salt) is sufficient. The reaction was carried out at 110 °C under thermal condition. This method, including some advantages such as mild reaction condition, easy work-up, and recoverable and reusable catalyst.A facile and efficient synthesis of bis(indolyl)methanes derivatives (3a-u) was reported via a condensation reaction of aldehydes and indole in the presence of by silica-supported-3-(triethoxysilyl) propane-1-ammonium chloride catalysis under solvent free conditions. We studied the reaction in different conditions and optimized. The use of just 0.02 g of (silica gel-ammonium salt) is sufficient. The reaction was carried out at 110 °C under thermal condition. This method, including some advantages such as mild reaction condition, easy work-up, and recoverable and reusable catalyst..