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Iranian Chemical Communication
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Volume Volume 7 (2019)
Volume Volume 6 (2018)
Issue Issue 4, pp. 325-460
Issue Issue 3, pp. 218-324
Issue Issue 2, pp. 109-217
Issue Issue 1, pp. 1-108
Volume Volume 5 (2017)
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Bhat, A. (2018). Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives. Iranian Chemical Communication, 6(Issue 2, pp. 109-217), 114-124.
Ajmal R Bhat. "Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives". Iranian Chemical Communication, 6, Issue 2, pp. 109-217, 2018, 114-124.
Bhat, A. (2018). 'Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives', Iranian Chemical Communication, 6(Issue 2, pp. 109-217), pp. 114-124.
Bhat, A. Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives. Iranian Chemical Communication, 2018; 6(Issue 2, pp. 109-217): 114-124.

Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives

Article 2, Volume 6, Issue 2, pp. 109-217, Spring 2018, Page 114-124  XML PDF (860 K)
Document Type: Original Research Article
Author
Ajmal R Bhat
Department of Natural Science, S.B.B.S.University, Jalandhar Punjab-144030 (India)
Abstract
Annulated pyrano[2,3-d]pyrimidine/pyrano[2,3-d]uracil derivatives were synthesized using aromatic aldehydes, active methylene compounds and barbituric acid in presence of dibutylamine (DBA) catalyst in ethanol as solvent. The different substituents on phenyl ring in the fused pyrano uracil skeleton showed productive influence on its antimicrobial activity against some gram positive and gram negative bacteria like Pseudomonas aureus, E. coli, Staphylococcus aureus, Klebsiella pneumonia and Bacillus cereus. Antibacterial screening revealed that the presence of heteroaryl, cyano and amino groups on uracil skeleton increases its penetrating power on bacterial cell wall and product becomes more biologically energetic. The antimicrobial activity results showed some definite and interesting facts about the structure activity relationship (SAR) of synthesized molecules.

Graphical Abstract

Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives
Keywords
Annulated uracils; structural dependent biological activity; gram positive; gram negative bacteria; pharmacophore sites
Main Subjects
Organic chemistry
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