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Iranian Chemical Communication
Articles in Press
Current Issue
Journal Archive
Volume Volume 7 (2019)
Volume Volume 6 (2018)
Issue Issue 4, pp. 325-460
Issue Issue 3, pp. 218-324
Issue Issue 2, pp. 109-217
Issue Issue 1, pp. 1-108
Volume Volume 5 (2017)
Volume Volume 4 (2016)
Volume Volume 3 (2015)
Volume Volume 2 (2014)
Volume Volume 1 (2013)
Mohammadi, B., Rezaei, E., Moghadami, F. (2018). Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes. Iranian Chemical Communication, 6(Issue 3, pp. 218-324), 218-227.
Bagher Mohammadi; Ebrahim Rezaei; Fouzieh Moghadami. "Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes". Iranian Chemical Communication, 6, Issue 3, pp. 218-324, 2018, 218-227.
Mohammadi, B., Rezaei, E., Moghadami, F. (2018). 'Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes', Iranian Chemical Communication, 6(Issue 3, pp. 218-324), pp. 218-227.
Mohammadi, B., Rezaei, E., Moghadami, F. Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes. Iranian Chemical Communication, 2018; 6(Issue 3, pp. 218-324): 218-227.

Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes

Article 1, Volume 6, Issue 3, pp. 218-324, Summer and Autumn 2018, Page 218-227  XML PDF (606 K)
Document Type: Original Research Article
Authors
Bagher Mohammadi 1; Ebrahim Rezaei2; Fouzieh Moghadami3
1Payame Noor University of Abhar
2Department of Chemistry, Payame Noor University, P. O. Box 19395-3697, Tehran, Iran
3Department of Biology, Payame Noor University, P. O. Box 19395-3697, Tehran, Iran
Abstract
This work described a simple and efficient method for the synthesis of 1-azabicyclo[3.1.0]hexane-3-ene derivatives. arylidenmalononitriles and hydroxylamine hydrochloride in the presence of NaOH, under microwave irradiation and solvent-free conditions produced the titled compounds in good to excellent yields. Using of simple chemicals, short reaction times, and solvent-free conditions, high yields of products, high atomic economy , and eco-friendly are the important advantages of this method. The antibacterial effect of 4-amino-2,6-bis(2,4-dichlorophenyl)-1-azabicyclo[3.1.0]hex-3-ene-3,5-dicarbonitrile was evaluated by minimum inhibitory concentration and disk diffusion method against the standard strains of Staphylococcus aureus and Pseudomonas aeruginosa. Minimum inhibitory concentrations of 2h were 40 and 30 mg/ml for P. aeruginosa and S. aureus respectively and the maximum inhibitory zones were 4 and 5 mm on average, respectively.

Graphical Abstract

Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes
Keywords
Azabicyclo; microwave irradiation; antibactery; solvent-free; staphylococcus
Main Subjects
Organic chemistry
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