Document Type : Original Research Article

Authors

1 shri muktanand college, gangapur, dist.-aurangabad

2 Department of Chemistry, Shri Muktanand College, Gangapur, Dist.-Aurangabad,Pin-431 109, Maharashtra

Abstract

Tetra-N-Butyl Ammonium Hydroxide was used as a catalyst for one-pot, three component

condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in

ethanol:water solvent system at 60oC. Current method has major advantages like mild reaction

conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst.
In conclusion, we have explored nicely the synthetic utility of TBAOH as a commercially available, efficient, mild, straightforward, simple, environmentally and economically friendly organo-basic catalyst for the synthesis of diverse Pyrano[2,3-d]pyrimidinone derivtives. Thus we have developed a novel, simple and highly efficient one potmulticomponent reaction protocol for the synthesis of Pyrano[2,3-d]pyrimidinone derivtives in ethanol:water solvent system.

Graphical Abstract

Tetra-N-Butyl ammonium hydroxide mediated one-pot synthesis of pyrano [2, 3-d] pyrimidinone derivatives

Keywords

Main Subjects

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