Document Type: Original Research Article


1 Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran

2 Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University

3 Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran


The species Heracleum rawianum belongs to Apiaceae, is one of the native species in Iran. The leaves and fruits of Heracleum rawianium are used traditionally in Iran as flavouring agent and spice for food. In the present work, the extraction of aerial parts of this plant with acetone by maceration is described. Our phytochemical analysis of the chloroform extract of the aerial parts of this plant afforded three condensed furocoumarins. Furocoumarins such as angelicin (in remarkable amount), allobergapten and sphondin were isolated and identified by IR, 1H-NMR, 13C-NMR and DEPT-135 spectroscopic data, MS spectrometery and camparison with the literature. To the best of our knowledge, no phytochemical investigations on this species have been reported.

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[1] M.G. Pimenov, M.V. Leonov, Turk J Bot., 2004, 28, 139-145.

[2] K.H. Rechinger, In Flora Iranica., Graz: Akademische Druck-u. Verlagsanstalt, 1982, 492-496.

[3] G. Amin. Popular medicinal plants of Iran, Tehran: Medical sciences publication of Shahid Beheshti University, 2008, 120-122.

[4] D.J. Newman, G.M. Cragg, J. Nat. Pro., 2007, 70, 461–477.

[5] H. Zhang, F. Chen , X. Wang , H.Y. Yao, Food Research Internatiol, 200639, 833–839.

[6] V. Hajhashemi, S.E. Sajjadi, M. Heshmati, J. Ethnopharmacol., 2009, 124, 475-480.

[7] A.K. Bogucka, H.D. Smolarz, J. Kocki, Fitoterapia., 2008, 79, 487-497.

[8] S. Dash, N.L. Kanta, S. Bhise, N. Bhuyanl, TJPR., 2005, 4, 341–347.

[9] M. Doi, T. Nakamori, M. Shibano, M. Taniguchi, N.H. Wang, K. Baba, Acta Cryst. C., 2004, 12, 833-835.

[10] W.L. Xiao, S.H. Li, Y.H. Shen, X.L. Li, H.D. Sun, Heterocycles, 2005, 65, 1189-1196.

[11] I. Orhan, F. Tosun, B. Sener. Z Naturforsch, C., 2008, 63, 366-370.

[12] S. Dash, S. Bhise, L.K. Nath, S. Bhattacharya, Asian J. Chem., 2006, 18, 1581-1582.

[13] G.K. Kasumova, S.V. Serkerov, Chem. Nat. Comp., 2011, 47, 358-359.

[14] T. Neill, J. Johnson, D. Webster, Ch. Gray, J. Ethnopharmacol., 2013, 147, 232-237.

[15] W. Steck and B.K. Bailey, Can. J. Chem., 1969, 47, 2425.

[16] ­S.D., Ibadullaeva and S.V., Serkerov, Chem. Nat. Comp., 2000, 36, 534.

[17] J.A. Parrish, R.S. Stern, M.A. Pathak, T.B. Fitzpatrick, Science of Photomedicine: New York: Plenum Press, 1982, 595-624.

[18] Y. Aynehchi, Z. Aliabadi, M.H. Salehi-Surmaghi, Acta Hort., 1978, 73, 103-107.

[19] L.L. Yang, Y.C. Liang, C.W. Chang, W.S. Lee, C.T. Kuo, C.C. Wang, H.M. Lee, C.H. Lin, Life Sci., 2002, 72, 199-213.

[20] F. Tosun, C. AkyüzKizilay, K. Erol, F. Sultan Kilic¸ M. Kürkcüoglu, K.H. Baser, Food Chem., 2008, 107, 990-993.