Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools

Josefa, Paat; Lauro, Figueroa; Maria, Lopez; Lenin, Hau; Francisco, Diaz; Elodia, Garcia; Eduardo, Pool; Marcela, Rosas; Virginia, Mateu

Document Type : Original Research Article

Authors

¹ University Autonomous of Campeche

² University Autonomous of campeche

³ IPN

⁴ Universidad Veracruzana

⁵ Universidad veracruzana

Abstract

The aim of this study was to synthesize a new oxetan-phenyltetrahydropyridazine-3,6-dione derivative (compound 6) using with different techniques. The first method was achieved by the preparation of a phenylhydrazine derivative (2) using three components system (3,17-aldol-estradiol, phenylhydrazine, 5-hexyn-3-ol) in presence of Copper(II). Then, 2 Was reacted with tert-butyldimethylsilyl chloride to form the compound 3 (trimethylbutan-silyloxy-steroid-hydrazine). Following, a pyridazine derivative (4); was prepared by the reaction of 3 with succinic acid using boric as catalyst. The compound 4 was reacted with hydrofluoric acid to form the a tetrahydropyridazine-3,6-dione (5). Finally, the preparation of 6 was carried out by the reaction of 5 with CopperII. Spectroscopy analyses NMR was used to confirm the chemical structure of compounds. In conclusion, in this study a facile method to synthesis of an oxetan-phenyltetrahydropyridazine-3,6-dione is reported.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

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Iranian chemical communication

Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools

References

References

[2] A. Anees, S. Mishra . M. Shaharyar, Eur. J. Med. Chem., 2010, 45, 2283-2290.

[3] D. Mantu, C. Moldoveanu, A. Nicolescu, C. Deleanu, Ultrasonics Sonochem., 2009, 16, 452-454.

Volume 6, Issue 3, pp. 218-324, Serial No. 20
July 2018
Pages 256-265

Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools

References

References

[2] A. Anees, S. Mishra. M. Shaharyar, Eur. J. Med. Chem., 2010, 45, 2283-2290.

[3] D. Mantu, C. Moldoveanu, A. Nicolescu, C. Deleanu, Ultrasonics Sonochem., 2009, 16, 452-454.

Volume 6, Issue 3, pp. 218-324, Serial No. 20July 2018Pages 256-265

[2] A. Anees, S. Mishra . M. Shaharyar, Eur. J. Med. Chem., 2010, 45, 2283-2290.

Volume 6, Issue 3, pp. 218-324, Serial No. 20
July 2018
Pages 256-265