Synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives under solvent-free condition

Hajinasiri, Rahimeh; Rezayati, Sobhan

Document Type : Original Research Article

Authors

¹ Department of Chemistry, Islamic Azad University, Qaemshahr Branch, P.O. Box 163, Qaemshahr, Iran

² Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran

Abstract

An efficient synthesis of Methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives via simple three-component reaction and one-pot reactions between isoquinoline, dimethyl acetylenedicarboxylate and N-phenylthiourea under solvent-free conditions without using any additional catalyst, is described. The mild reaction conditions and good yields and exhibit the synthetic advantage of this method. Also this method is environmentally friendly. The methods of green chemistry continue to grow in importance. Alternative processes help to conserve resources and can even reduce costs. The replacement of convention solvents with water or solvent-free conditions, which is harmless to health and is available in large quantities. The thiazolium rings are key units in agricultural compounds and drugs.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

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Iranian chemical communication

Synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives under solvent-free condition

References

References

Volume 3, Issue 2, pp. 72-147, Serial No. 7
April 2015
Pages 132-136

Synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives under solvent-free condition

References

References

Volume 3, Issue 2, pp. 72-147, Serial No. 7April 2015Pages 132-136

Volume 3, Issue 2, pp. 72-147, Serial No. 7
April 2015
Pages 132-136