LaCl3.7H20: An efficient catalyst for one-pot multi-component synthesis of 1,4-polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction

Somwanshi, Abhijeet; Pandit, Yashwant Bhaskar; Gholap, Akash; Ghogare, Rushikesh; Pandit, Shivaji

Document Type : Original Research Article

Authors

¹ Research Centre and Post Graduate Department of Chemistry, PadmashriVikhePatil College of Arts, Science and Commerce Pravaranagar At./Po. Lonikd. Tal.Rahata. Dist. Ahmednagar. 413713. (MS). India. (Affiliated to SavitribaiPhule Pune University, Pune)

² Applied Chemistry Division, DIAT-DRDO, Girinagar, Pune. 411025.(MS) India.

³ Research Centre and Post Graduate Department of Chemistry, PadmashriVikhe Patil College of Arts, Science and Commerce Pravaranagar At./Po. Lonikd. Tal.Rahata. Dist. Ahmednagar. 413713. (MS). India. (Affiliated to Savitribai Phule Pune University, Pune)

⁴ Research Centre and Post Graduate Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce Pravaranagar At./Po. Lonikd. Tal.Rahata. Dist. Ahmednagar. 413713. (MS). India. (Affiliated to Savitribai Phule Pune University, Pune)

⁵ Post Graduate and Research Centre, Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce Pravaranagar, (Loni kd) Tal. Rahata. Dist. Ahmednagar 413713 (MS) India.

Abstract

An efficient one pot multi component synthesis of 1, 4-Polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction using lanthanum chloride heptahydrate (LaCl3.7H2O) from an aromatic aldehyde, ethyl acetoacetate, dimedone and ammonium acetate as a nitrogen precursor in ethanol at room temperature is described. In the present work we report lanthanum chloride heptahydrate remarkably non-toxic in nature and ease of handling we explored the utility of lanthanum chloride as a catalyst for the synthesis of 1, 4-polyhydroquinoline derivatives. We newly report p-N, N-dimethylamino-cinnamaldehyde and m-chlorobenzaldehyde for the synthesis of 1, 4-Polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction and was characterized by IR and 1HNMR spectroscopic methods.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

References

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Iranian chemical communication

LaCl3.7H20: An efficient catalyst for one-pot multi-component synthesis of 1,4-polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction

References

References

Volume 5, Issue 3, pp. 237-363, Serial No. 16
July 2017
Pages 293-300

LaCl3.7H20: An efficient catalyst for one-pot multi-component synthesis of 1,4-polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction

References

References

Volume 5, Issue 3, pp. 237-363, Serial No. 16July 2017Pages 293-300

Volume 5, Issue 3, pp. 237-363, Serial No. 16
July 2017
Pages 293-300