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Efficient one-pot synthesis of 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates catalyzed by nano MgO in water

Document Type : Original Research Article

Authors

1 Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

2 Islamic Azad University, Rasht branch, Iran

Abstract

Water is a versatile solvent in many ways, and in this sense performing organic reactions in this medium is now of great interest. The one-pot reaction of ethyl acetoacetate or benzyl acetoacetate, with benzaldehydes and malononitrile to provide some novel 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates has been performed over nano MgO with high performance in water as a green solvent at 80 °C. The nanocrystalline MgO catalyst was characterized via X-ray diffraction (XRD), transmission electron microscopy (TEM) and BET analysis. This method offers considerable improvements for the synthesis of 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates with concern to the yield of products, facility in operation, and green aspects without using of toxic catalysts and solvents.

Graphical Abstract

Efficient one-pot synthesis of 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates catalyzed by nano MgO in water

Keywords

Main Subjects

References
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Iranian chemical communication
Volume 6, Issue 2, pp. 109-217, Serial No. 19
April 2018
Pages 125-133
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