Guanidine hydrochloride: An efficient catalyst for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives under solvent free conditions

Pandit, Shivaji Sandu; Pardhe, Sonali Shivaji; Pandit, Yashwant Bhaskar

Document Type : Original Research Article

Authors

¹ Post Graduate and Research Centre, Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce Pravaranagar, (Loni kd) Tal. Rahata. Dist. Ahmednagar 413713 (MS) India.

² Post Graduate and Research Centre, Department of Chemistry, Padmashri Vikhe Patil College Pravaranagar 413713. Tal Rahata Dist. Ahmednagar (MS) India

³ bApplied Chemistry Division, DIAT-DRDO, Girinagar, Pune. 411025.(MS) India

Abstract

A Highly efficient protocol has been developed for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives installing a one pot three component coupling reaction of an aromatic aldehyde, thiosemicarbazide and maleic anhydride using guanidine hydrochloride as highly inexpensive and environmentally friendly catalyst under solvent free condition at 1200C with good to excellent yields, It offers short reaction time, good to excellent yields and simple and easy workup procedure as compared to the traditional methods of synthesis. The products are characterized by spectroscopic methods like IR and 1H NMR. In the present protocol we reports unsaturated aldehydes first time using guanidine hydrochlori with excellent yields.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

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Iranian chemical communication

Guanidine hydrochloride: An efficient catalyst for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives under solvent free conditions

References

References

Volume 5, Issue 2, pp. 121-236, Serial No. 15
April 2017
Pages 227-236

Guanidine hydrochloride: An efficient catalyst for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives under solvent free conditions

References

References

Volume 5, Issue 2, pp. 121-236, Serial No. 15April 2017Pages 227-236

Volume 5, Issue 2, pp. 121-236, Serial No. 15
April 2017
Pages 227-236