Document Type : Original Research Article

Authors

• Mahdieh Chegeni ¹
• Ardeshir Khazaei ²
• Shahnaz Saednia ³

¹ Ayatolah al ozma bourojerdi

² Faculty of Chemistry, Bu-Ali Sina University, P.O. Box 651783868, Hamedan, Iran

³ Young Researchers & Elites Club, Toyserkan Branch, Islamic Azad University, Toyserkan, Iran

Abstract

Nanocrystalline SiO2–HClO4, as a newly reported catalyst, has been used as an efficient and reusable catalyst for the synthesis of pyrimidine derivatives. The procedure can be successfully applied to the efficient synthesis of mono substituted pyrimidine derivatives, using triethyl orthoformate, ammonium acetate, methyl ketone derivatives. In practice, this method is a combination of a satisfactory synthesis and more significantly easy product isolation and purification. A simple, high yielding in the presence of perchloric acid–functionalized silica nanosphere as a catalyst is described. The catalyst could be used at least five times without any change in the activity. Full characterization of the catalyst was performed by XRD, EDX, UV–Vis, TGA spectra and also by SEM and TEM images.

Graphical Abstract

Keywords

• three-component reaction
• pyrimidine derivative
• perchloric acid–functionalized silica nanosphere
• methyl ketones

Main Subjects

• Nanochemistry