An efficient one-Pot green synthesis of 4H-Benzo[b]pyrans using guanidinium chloride as polyfunctional organocatalyst

Sadeghpour, Mahdieh

Document Type : Original Research Article

Author

Mahdieh Sadeghpour

Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan, Iran

Abstract

A simple, efficient, and high yielding one-pot protocol has been developed for the synthesis of 4H-benzo[b]pyrans scaffolds installing a three-component tandem Knoevenagel-cyclocondensation reaction of an aldehyde, malononitrile and dimedone using guanidinium chloride as polyfunctional organocatalyst under solvent-free conditions in high to excellent yields. Various aromatic aldehydes were utilized in the reaction and in all situations the desired product were synthesized successfully. The advantageous features of this methodology are operational simplicity, convenient work-up procedures, shorter reaction time and avoiding the use of toxic solvents and purification of products by non-chromatographic methods. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

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Iranian chemical communication

An efficient one-Pot green synthesis of 4H-Benzo[b]pyrans using guanidinium chloride as polyfunctional organocatalyst

References

References

Volume 4, Issue 1, pp. 1-132, Serial No. 10
January 2016
Pages 57-66

An efficient one-Pot green synthesis of 4H-Benzo[b]pyrans using guanidinium chloride as polyfunctional organocatalyst

References

References

Volume 4, Issue 1, pp. 1-132, Serial No. 10January 2016Pages 57-66

Volume 4, Issue 1, pp. 1-132, Serial No. 10
January 2016
Pages 57-66