Synthesis of some network polymers with siloxane units as a drug delivery system

Galehassadi, Mohammad; Omidi, Samad

Document Type : Original Research Article

Authors

Mohammad Galehassadi ¹
Samad Omidi ²

¹ Azarbaijan Shahid Madani University

² Azarbaijam Shahid Madani University

Abstract

New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by ter polymerization of methacrylic acid (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy) methylsilane (VBM) in the presence of some new cross-linking agents.
The monomers and polymers were characterized by FT-IR and 1H-NMR spectroscopy, and their thermal stability studied by DSC analysis. The hydrolysis of them were carried out in cellophane membrane dialysis bags containing aqueous buffer solution at 37 C. Detection of the hydrolysis product by UV spectroscopy method showed that attaching of siloxane units in these hydrogels modified this drug delivery system.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

References

[1] M. G. Assadi and N. Golipour, Designed Monomers and Polymers, 2007, 1–11

[2] M. Mahkam, M.G. Assadi, and R. Mohammadzadeh, Macromolecular Research, 2006, 14, 1, 34-37

(2006).

[3] K. Malcolm, “Influence of Silicone Elastomer Solubility and Diffusivity on the In Vitro Release of Drugs from Intravaginal Rings,” Journal of Controlled Release, 2003, 90, 2, 217–225.

[4] M. Ghannam, K. Tojo, and Y. Chien, Kinetics and Thermodynamics of Drug Permeation through Silicone Elastomers (I) Effect of Penetrant Hydrophilicity (New York: Marcel Dekker., 1986, 303–325.

[5] S Nabahi. Intravaginal drug-delivery device. U.S. Patent., 1998, 6,039,968, 22, and 2000, issued July 9.

[6] C. Passmore et al. Intravaginal drug-delivery devices for the administration of testosterone and testosterone precursors. , 2000, 6,416,780, filed May 1.

[7] Suh YW, Kung MC, Wang YM. JACS. 2006, 128, 9, 2776-2777.

[8] M. Cazacu, C.Racles, A. Airinei, Degaradable polymers. Siloxanes in hydrolitically degradable polymeric structures Material Plastice., 2005, 42, 1, 12-16.

[9] S.Brahim, D.Narinesingh, A. Guiseppi-Elie, BIOMACROMOLECULES. 2003, 4, 5 1224-1231.

[10] M. Kajihara, T. Sugie, A. Sano, K. Fujioka, Y. Urabe, M. Tanihara and Y. Imanishi, Chemical and Pharma Bulletin., 2003, 51, 11-14.

[11] K. Malcolm et al, Journal of Controlled Release, 2003, 90, 2, 217–225.

[12] L. Ren, A. Osaka, B. Yu, Bioactive gelatin-siloxane hybrids as tissue engineering scaffold. Science and Technology of Hybrid Materials Book Series: Soild State Phenomena. 2006, 111, 13-18.

[13] Passmore and Clare and Gilligan and Clare, U.S. Pat., 2002, 6,416,780.

[14] S.M. Xing, Y.L. Wang, Synthetic Techniques of Organic Silicon and

Application of Its Products, Chemical Industry Press, 2001, 382.

Iranian chemical communication

Synthesis of some network polymers with siloxane units as a drug delivery system

References

References

Volume 3, Issue 4, pp. 283-387, Serial No. 9
October 2015
Pages 323-334

Synthesis of some network polymers with siloxane units as a drug delivery system

References

References

Volume 3, Issue 4, pp. 283-387, Serial No. 9October 2015Pages 323-334

Volume 3, Issue 4, pp. 283-387, Serial No. 9
October 2015
Pages 323-334