Iranian chemical communication 2423-4958 3 Issue 2, pp. 72-147, Serial No. 7 2015 04 01 A new facile route to synthesize thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 114 120 990 EN Mehdi Soleimany Payame Noor University (PNU) Jalil Lari Payame Noor University of Mashhad Hooshang Vahedi Payame Noor University of Mashhad Morteza Imanpour Payame Noor University of Mashhad Journal Article 2014 07 02 A new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air oxidation. The products were obtained in high yield with an easy work-up in simple reaction along with the purification of products by non-chromatographic method. This general synthetic procedure can be extended to the preparation of a wide variety of isomeric triazoles using 2-amino thiophene-3-carboxamide bifunctional derivatives. https://icc.journals.pnu.ac.ir/article_990_64c0478c874aeb47e50c95b79b0dacdb.pdf