Iranian chemical communication 2423-4958 3 Issue 2, pp. 72-147, Serial No. 7 2015 04 01 Three-component procedure for the synthesis of new chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition 96 104 979 EN Mohammad Javad Taghizadeh Department of Chemistry, School of Sciences University of Imam Hossein, Tehran, Iran Khosrow Jadidi Department of Chemistry, Shahid Beheshti University, G.C. Tehran 1983963113, Iran Journal Article 2014 06 29 The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindolesvia a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophilewas described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–Cu(II)triflate complex as catalyst.The reaction mechanism is discussedon the basis of the assignment of the absolute configuration of the cycloadducts.<br /><br />The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindolesvia a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophilewas described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–Cu(II)triflate complex as catalyst.The reaction mechanism is discussedon the basis of the assignment of the absolute configuration of the cycloadducts. https://icc.journals.pnu.ac.ir/article_979_200308267ea4e560812fe172c17aa549.pdf