Iranian chemical communication 2423-4958 5 Issue 1, pp. 1-120, Serial No. 14 2017 01 01 Indium chloride (InCl3) catalysed domino protocol for the regioselective synthesis of highly functionalized pyranopyrazoles under mild conditions 105 114 2637 EN Hemant Chavan Organic Chemistry Research Laboratory, Department of Chemistry, Rajaram College Kolhapur, Maharashtra, India Datta Survase Department of Chemistry, A.S.P. College Devrukh, Dist-Ratnagiri, Maharashtra, India-415804 Sakharam Dongare Medicinal chemistry Research Laboratory, School of Chemical Science, Solapur University Solapur, Maharashtra, India-413255 Vasant Helavi Medicinal chemistry Research Laboratory, School of Chemical Science, Solapur University Solapur, Maharashtra, India-413255 Shreeram Ganapure Organic Chemistry Research Laboratory, Department of Chemistry, Rajaram College Kolhapur, Maharashtra, India Journal Article 2015 12 31 Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions preceeded within a short period of time with excellent purity. All of the synthesized compounds were identified by IR, 1H NMR, 13C NMR and mass spectroscopy. Quantitative yields, inexpensive and environmentally friendly solvent system and simple work-up procedure are the attractive features of the present method. It is thus enviro-economic method without producing hazardous wastes. The formed pyranopyrazoles might find to possess important biological and pharmaceutical applications. https://icc.journals.pnu.ac.ir/article_2637_1e630be1dd8fdab016d9bdf211f938f6.pdf