Iranian chemical communication 2423-4958 4 Issue 2, pp. 133-235, Serial No. 11 2016 04 01 Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature 186 197 2049 EN Vinod Kamble Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-440001 Maharashtra, India. Sandeep Atkore School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Maharashtra, India. Parshuram Pisal School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Maharashtra, India. Munazza Sadaf Department of Chemistry, Institute of Science, Nagpur Renuka V. Thakre Department of Chemistry, Institute of Science, Nagpur Journal Article 2015 03 07 The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabutylammonium bromide (TBAB) and cesium carbonate in methanol. In the present method, the use of thermal condition is avoided. In addition, the advantages such as operational simplicity, economic viability, ecologically benign nature make this protocol a very efficient alternative to the literature methods. https://icc.journals.pnu.ac.ir/article_2049_0e4053c5d645a1575e77fa11481e6ea0.pdf