Iranian chemical communication 2423-4958 4 Issue 1, pp. 1-132, Serial No. 10 2016 01 01 The three-component reaction of 2-(2-oxopropyl)isoindoline-1,3-dione with alkyl isocyanides and aromatic carboxylic acids under catalyst-free conditions in water 42 56 1743 EN Ali Jafari UNIVERSITY of ZANJAN Ali Ramazani zanjan university Sang Woo Joo Yeungnam University Yavar Ahmadi University of Zanjan Fariba Sadri Payame Noor University Pegah Azimzadeh Asiabi University of Zanjan Journal Article 2015 04 24 A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side product and the products were obtained without any purification. The structures of the products were deduced from their 1H NMR, 13C NMR and IR spectra. The present methodology offers several advantages such as a simple procedure, catalyst-free, mild reaction conditions, high yields, and the absence of any volatile and hazardous organic solvents. https://icc.journals.pnu.ac.ir/article_1743_7c5f548584f7204ba6a29b6dcfebdfd5.pdf