Organic chemistry
Amira A. Ghoneim; Mohamed G. Assy; Enaiat K. Mohamed; Islam Ragab
Volume 5, Issue 2, pp. 121-236, Serial No. 15 , April 2017, , Pages 195-206
Abstract
Acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine ...
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Acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecular cycloaddition while it was reacted with N-methyl aniline affording thiazine derivative (7). In addition, it was reacted with cyanoacetamide producing mercaptopyrimidine derivative (9). Finally, compound (1) was refluxed with phenylhydrazine, urea, guanidinum carbonate and anthranilic acid in the presence of dry acetone affording triazole derivative (11), N-substituted pyrimidine (15), compound (18) and thiopyrimidine derivative (19) respectively. The structures of the new compounds were confirmed on the basis of elemental and spectral data. Some of the synthesized compounds were screened as anticancer.
Organic chemistry
Mehdi Foruzani; Abbas Ali Dehpour; Mahla Musavi
Volume 3, Issue 4, pp. 283-387, Serial No. 9 , October 2015, , Pages 283-290
Abstract
Stachys is one of the largest genera in the flowering plant family. It is in the subfamily Lamioideae (Labiatae), spreading and growing in different parts of Iran. The purpose of this study was to investigate the chemical properties of Stachyslavandulifolia as well as the essence, ethanol and methanol ...
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Stachys is one of the largest genera in the flowering plant family. It is in the subfamily Lamioideae (Labiatae), spreading and growing in different parts of Iran. The purpose of this study was to investigate the chemical properties of Stachyslavandulifolia as well as the essence, ethanol and methanol extracts of this plant. It was collected from Chulus located in the West of Mazandaran Province. The ethanol and methanol extracts were provided using soxhlet and percolation. The extracts then were defatted and solvent removal performed in a subsequent process. The anticancer activity of extracts was also conducted using MTT assay method in this respect. The test results indicated that there is no significant effect on the inhibition of cell growth when the concentration of extracts is lower than 0.5 mg/ml clarifying that the more the increase in concentration, the more the reduction in growth inhibition.