Organic chemistry
Bagher Mohammadi; Ebrahim Rezaei; Fouzieh Moghadami
Volume 6, Issue 3, pp. 218-324, Serial No. 20 , July 2018, , Pages 218-227
Abstract
This work described a simple and efficient method for the synthesis of 1-azabicyclo[3.1.0]hexane-3-ene derivatives. arylidenmalononitriles and hydroxylamine hydrochloride in the presence of NaOH, under microwave irradiation and solvent-free conditions produced the titled compounds in good to excellent ...
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This work described a simple and efficient method for the synthesis of 1-azabicyclo[3.1.0]hexane-3-ene derivatives. arylidenmalononitriles and hydroxylamine hydrochloride in the presence of NaOH, under microwave irradiation and solvent-free conditions produced the titled compounds in good to excellent yields. Using of simple chemicals, short reaction times, and solvent-free conditions, high yields of products, high atomic economy , and eco-friendly are the important advantages of this method. The antibacterial effect of 4-amino-2,6-bis(2,4-dichlorophenyl)-1-azabicyclo[3.1.0]hex-3-ene-3,5-dicarbonitrile was evaluated by minimum inhibitory concentration and disk diffusion method against the standard strains of Staphylococcus aureus and Pseudomonas aeruginosa. Minimum inhibitory concentrations of 2h were 40 and 30 mg/ml for P. aeruginosa and S. aureus respectively and the maximum inhibitory zones were 4 and 5 mm on average, respectively.
Organic chemistry
Mohammad Ali Nasseri; Ali Allahresani; Batol Zakeri Nasab
Volume 3, Issue 2, pp. 72-147, Serial No. 7 , April 2015, , Pages 78-85
Abstract
Microwave assisted green synthesis of α, ά- bis (substituted- benzylidene) alkanones by the crossed- aldol condensation reaction of substituted aryl aldehydes with ketones in the presence of catalytic amount of NbCl5 in good to excellent yields. This reaction is carried out under solvent-free ...
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Microwave assisted green synthesis of α, ά- bis (substituted- benzylidene) alkanones by the crossed- aldol condensation reaction of substituted aryl aldehydes with ketones in the presence of catalytic amount of NbCl5 in good to excellent yields. This reaction is carried out under solvent-free conditions. The results showed that aldehydes bearing electron–donating substituent's on phenyl-ring favored the formation of product in good to excellent yields with reaction times ranging between 3 and 7 min. In addition, furfural, cinamaldehyde, thiophene-2-carbaldehyde and 5-methylthiophene-2-carbaldehyde were investigated in aldol reaction, and the results showed excellent yields. Also, the reactions were carried out at room & thermal (80 0C) conditions. The results showed that the yields are in accordance with the microwave irradiations, But the time is 1.5-5 h at room temperature and 15-45 min in thermal conditions.
Organic chemistry
Seyed Mohammad Vahdat; Abbas Mohammadzadeh; Esmaiel Derafshian; Somaieh Akhoondi
Volume 2, Issue 2, pp. 82-163, Serial No. 3 , April 2014, , Pages 157-163
Abstract
In the present study, Aminoazines were prepared from the reaction of amidrazone hydroiodide with various aromatic aldehydes in the presence of a solid base under microwave irradiation with power level of 850 W for 2-7 min in high yields. The amidrazone hydroiodide can also be prepared by the reaction ...
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In the present study, Aminoazines were prepared from the reaction of amidrazone hydroiodide with various aromatic aldehydes in the presence of a solid base under microwave irradiation with power level of 850 W for 2-7 min in high yields. The amidrazone hydroiodide can also be prepared by the reaction of S-methyl isothiobenzamide hydroiodide and hydrazine in methanol under nitrogen gas. All synthesized compounds were characterized on the basis of IR and 1H NMR spectral data. The significant features of this method are short reaction times, high yields of the products, solvent free reaction, easy work-up procedure, directly production of aminoazines.