Organic chemistry
Mohammad Alikarami; Ahmad Nikseresht; Tayebeh Amoozadeh
Abstract
Benzimidazoles are among the most important nitrogen-containing heterocyclic compounds that have many pharmaceutical applications; including, antitumor, anticancer, anticorrosive, antibacterial, irritant and enzymatic interceptors. In this research, the synthesis of benzimidazoles using o-phenylenediamine ...
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Benzimidazoles are among the most important nitrogen-containing heterocyclic compounds that have many pharmaceutical applications; including, antitumor, anticancer, anticorrosive, antibacterial, irritant and enzymatic interceptors. In this research, the synthesis of benzimidazoles using o-phenylenediamine and aldehyde derivatives in the presence of the nano montemurillonite in solvent-free and room temperature conditions has been investigated. All products with relatively good yields were identified by spectral and physical methods.
Organic chemistry
Abbas Amini Manesh; Ardeshir Khazaei; Maedeh Gohari; Mahdieh Chegeni; Shahnaz Saednia
Volume 5, Issue 3, pp. 237-363, Serial No. 16 , July 2017, , Pages 308-314
Abstract
Methoxymethylation of a variety of alcohols was performed using formaldehyde dimethyl acetal in the presence of 1,3-dichloro-5,5-dimethyl hydantoin [DCDMH] and Poly N,N′-dibromo-N-ethyl naphthyl-2,7-disulfonamide [PBNS] as catalysts at room temperature and under solvent-free conditions. Our experiments ...
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Methoxymethylation of a variety of alcohols was performed using formaldehyde dimethyl acetal in the presence of 1,3-dichloro-5,5-dimethyl hydantoin [DCDMH] and Poly N,N′-dibromo-N-ethyl naphthyl-2,7-disulfonamide [PBNS] as catalysts at room temperature and under solvent-free conditions. Our experiments show that primary and secondary alcohols can be smoothly converted into the corresponding MOM-ethers in excellent yields. The methoxymethyl ethers (MOM-ethers) were obtained with good to excellent yields. 1,3-Dichloro-5,5-dimethyl hydantoin [DCDMH] and Poly N,N′-dibromo-N-ethyl naphthyl-2,7-disulfonamide [PBNS] effectively catalyzed the methoxymethylation of alcohols with dimethoxymethane at ambient temperature. The notable advantages of this method are mild reaction conditions, high yields, cheapness, safety and eco-friendliness, and recyclability of the catalysts.
Organic chemistry
Mohammad Reza Poor Heravi; Aazam Monfared Monfared; Masoumeh Ahmadi
Volume 4, Issue 4, pp. 359-490, Serial No. 13 , October 2016, , Pages 433-448
Abstract
A facile and efficient synthesis of bis(indolyl)methanes derivatives (3a-u) was reported via a condensation reaction of aldehydes and indole in the presence of by silica-supported-3-(triethoxysilyl) propane-1-ammonium chloride catalysis under solvent free conditions. We studied the reaction in different ...
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A facile and efficient synthesis of bis(indolyl)methanes derivatives (3a-u) was reported via a condensation reaction of aldehydes and indole in the presence of by silica-supported-3-(triethoxysilyl) propane-1-ammonium chloride catalysis under solvent free conditions. We studied the reaction in different conditions and optimized. The use of just 0.02 g of (silica gel-ammonium salt) is sufficient. The reaction was carried out at 110 °C under thermal condition. This method, including some advantages such as mild reaction condition, easy work-up, and recoverable and reusable catalyst.A facile and efficient synthesis of bis(indolyl)methanes derivatives (3a-u) was reported via a condensation reaction of aldehydes and indole in the presence of by silica-supported-3-(triethoxysilyl) propane-1-ammonium chloride catalysis under solvent free conditions. We studied the reaction in different conditions and optimized. The use of just 0.02 g of (silica gel-ammonium salt) is sufficient. The reaction was carried out at 110 °C under thermal condition. This method, including some advantages such as mild reaction condition, easy work-up, and recoverable and reusable catalyst..
Organic chemistry
Mohammad Reza Poor Heravi; Mohammad Amirloo
Volume 3, Issue 1, pp. 1-71, Serial No.6 , January 2015, , Pages 62-71
Abstract
A simple, clean, and environmentally benign three-component process for the synthesis of 2-amino-4Hchromenes using [mim]Cl, as an efficient catalyst under solvent-free conditions are described. A wide range of aromatic aldehydes easily undergoes condensations with 1-naphthol and malononitrile under solvent-free ...
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A simple, clean, and environmentally benign three-component process for the synthesis of 2-amino-4Hchromenes using [mim]Cl, as an efficient catalyst under solvent-free conditions are described. A wide range of aromatic aldehydes easily undergoes condensations with 1-naphthol and malononitrile under solvent-free conditions to afford the desired products of good purity in excellent yields. Taking into account environmental and economical considerations, the protocol presented here has the merits of environmentally benign, simple operation, convenient work-up and good yields. Furthermore, the catalyst can be easily recovered and reused for at least five cycles without losing its activities.A simple, clean, and environmentally benign three-component process for the synthesis of 2-amino-4Hchromenes using [mim]Cl, as an efficient catalyst under solvent-free conditions are described. A wide range of aromatic aldehydes easily undergoes condensations with 1-naphthol and malononitrile under solvent-free conditions to afford the desired products of good purity in excellent yields. Taking into account environmental and economical considerations, the protocol presented here has the merits of environmentally benign, simple operation, convenient work-up and good yields. Furthermore, the catalyst can be easily recovered and reused for at least five cycles without losing its activities.
Organic chemistry
Sobhan Rezayati; Zahra Erfani; Saman Rezayati; Rahimeh Hajinasiri; Marzieh Rekavandi
Volume 2, Issue 1, pp. 1-81, Serial No. 2 , January 2014, , Pages 72-81
Abstract
1,1-Diacetates(acylals) were prepared by direct condensation of various aldehydes with acetic anhydride using dipyridine cobalt chloride (CoPy2Cl2) as an efficient and green catalyst under solvent-free conditions at room temperature. The important features of this catalyst method are that the catalyst ...
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1,1-Diacetates(acylals) were prepared by direct condensation of various aldehydes with acetic anhydride using dipyridine cobalt chloride (CoPy2Cl2) as an efficient and green catalyst under solvent-free conditions at room temperature. The important features of this catalyst method are that the catalyst is solid, stable at high temperatures, soluble in water, stable in air, immiscible in common organic solvents, low toxic and, above all, it is reusable. CoPy2Cl2 can be recycled after a simple work-up and reused at least five runs without appreciable loss of its catalytic activity. High chemo-selectivity toward aldehyde in the presence of ketones is another advantage of the present method which provides selective protection of aldehydes in their mixtures with ketones.