Organic chemistry
Asadollah Farhadi; Milad Ramyar; Mohammad Ali Takassi
Volume 6, Issue 3, pp. 218-324, Serial No. 20 , July 2018, , Pages 266-270
Abstract
A protocol for the synthesis of 1,4-dihydropyridines (Hantzsch type-products) was developed by means of a three-component condensation of an aldehyde, a β-dicarbonyl compound, ammonium acetate and nano Al2O3/KF as catalyst. This reaction was carried out under different conditions including i) solvent-free ...
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A protocol for the synthesis of 1,4-dihydropyridines (Hantzsch type-products) was developed by means of a three-component condensation of an aldehyde, a β-dicarbonyl compound, ammonium acetate and nano Al2O3/KF as catalyst. This reaction was carried out under different conditions including i) solvent-free ii) and reflux in different solvents. In all conditions, the desired products were obtained in high yields after relatively short reaction times. Nevertheless, the reactions proceed faster and in higher yields when they were carried out in ethanol. Compared to the classical Hantzsch reaction conditions and previously reported protocols, this protocol has the advantages of consistently excellent yields and short reaction times. After the reaction, the catalyst could be recovered easily.