Organic chemistry
Reyhaneh Khoeiniha; Ali Ezabadi; Abolfazl Olyaei
Volume 4, Issue 3, pp. 236-358, Serial No. 12 , July 2016, , Pages 273-282
Abstract
A facile and efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes has been developed by one-pot Knoevenagel condensation, Michael addition and cyclodehydration reaction of dimedone (active methylene carbonyl compound) with aromatic aldehydes in the presence of Iron (III) sulfate hydrate ...
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A facile and efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes has been developed by one-pot Knoevenagel condensation, Michael addition and cyclodehydration reaction of dimedone (active methylene carbonyl compound) with aromatic aldehydes in the presence of Iron (III) sulfate hydrate as a solid acidic catalyst under solvent-free conditions. Various aromatic aldehydes were utilized in the reaction and in all situations the desired product were synthesized successfully. The present methodology is cost-effective in addition to other advantages like high yields of products in shorter reaction time and simple workup procedure. The non toxicity and easy availability of the catalyst makes this protocol efficient and environmentally benign.
Organic chemistry
Abolfazl Olyaei; Zohreh Derikvand; Fatemeh Noruzian; Mahdieh Sadeghpour
Volume 4, Issue 3, pp. 236-358, Serial No. 12 , July 2016, , Pages 337-346
Abstract
Al-MCM-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. The reaction was efficiently promoted by 10 mg ...
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Al-MCM-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. The reaction was efficiently promoted by 10 mg nano-Al-MCM-41 and the heterogeneous catalyst was recycled for four runs in this reaction without losing its catalytic activity. The key advantages of this process are operational simplicity, reusable catalyst, shorter reaction time, convenient work-up procedures, avoiding the use of organic solvents and purification of products by non-chromatographic methods. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity.