Organic chemistry
Mehdi Nabati; Mehrdad Mahkam; Hassan Heidari
Volume 2, Issue 4, pp. 236-325, Serial No. 5 , October 2014, , Pages 236-243
Abstract
Turmeric (Curcuma longa L.) is extensively used as a spice, food preservative and colouring material. It has been used in traditional medicine for various diseases. Curcumin, the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. Heretofore, it has ...
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Turmeric (Curcuma longa L.) is extensively used as a spice, food preservative and colouring material. It has been used in traditional medicine for various diseases. Curcumin, the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. Heretofore, it has been reported that natural colored extracts isolated from turmeric rhizomes with many methods such as maceration, digestion, microwave and infusion. In this paper, it was tried to isolate and characterize curcumin from the curcumin rhizomes marketed in Maragheh city of Iran by soxhlet extraction technique in methanol solvent. The advantage of this technique is the isolation of large amounts of curcumin (208 mg from 25 g turmeric rhizomes powder) with smaller quantity of methanol.
Organic chemistry
Mehdi Nabati; Mehrdad Mahkam
Volume 2, Issue 3, pp. 162-231, Serial No. 4 , July 2014, , Pages 162-167
Abstract
2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these ...
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2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't selective in secondary amines preparation. Also, the selective synthesis of secondary amines is a problematic field in organic chemistry. 2,6-diaminopyridine can be selective N-methylated from reaction of this compound with sodium azide and orthoformic ester in low time with good yields.
Organic chemistry
Mehdi Nabati; Mehrdad Mahkam
Volume 2, Issue 2, pp. 82-163, Serial No. 3 , April 2014, , Pages 129-136
Abstract
Abstract:Turmeric is a member of the ginger family (Zingiberaceae), which is extensively used as a spice, food preservative and colouring material. Curcumin is a main bioactive natural compound derived from the rhizome of this plant. Curcumin can exist in several tautomeric forms, keto and enol. The ...
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Abstract:Turmeric is a member of the ginger family (Zingiberaceae), which is extensively used as a spice, food preservative and colouring material. Curcumin is a main bioactive natural compound derived from the rhizome of this plant. Curcumin can exist in several tautomeric forms, keto and enol. The keto form is more stable than enol form. Silyl ethers have proven to be versatile substrates for a wide variety of organic reactions and they are prepared by reacting an alcohol and a silicon halide using a base such as triethylamine in stoichiometric quantity. Curcumin silyl ether derivatives were prepared under mild conditions. The stability of products decreases with increasing size of the silyl substitutions and the products will be unstable.
Organic chemistry
Mehrdad Mahkam; Mehdi Nabati; Hadieh Rahbar Kafshboran
Volume 2, Issue 1, pp. 1-81, Serial No. 2 , January 2014, , Pages 34-38
Abstract
Lawsone a natural pigment present in the henna leaves has been used as a skin and hair dye since 1400 BC. The concentration of this natural compound in leaves varies from place to place depending upon many of the environmental factors and the highest quantity reported so far is about 1% of the dry mass. ...
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Lawsone a natural pigment present in the henna leaves has been used as a skin and hair dye since 1400 BC. The concentration of this natural compound in leaves varies from place to place depending upon many of the environmental factors and the highest quantity reported so far is about 1% of the dry mass. Heretofore, it has been reported that natural colored extracts and isolate from Henna leaves with many methods such as maceration, digestion, microwave and infusion. In this paper, regarding the therapeutic effects and traditional applications of henna, it was tried to isolate and characterize Lawsone from the henna leaves marketed in Tabriz city of Iran by soxhlet extraction technique in methanol solvent. The advantage of this technique is the isolation of large amounts of lawsone (720 mg from 40 g henne leaves powder) with smaller quantity of methanol.