Document Type: Original Research Article


1 Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran

2 Department of parasitology & Mycology, school of Medicine, Arak University of Medical Sciences, Arak, Iran



The purpose of the present study was investigating kinetic and thermodynamic analysis using eudragit (EUD) polymer as controller to drug release mebendazole. nanofibers containing various proportions of EUD polymer, that were prepared with electrospinning technique.  In this study, the amount of drug mebendazole release was investigated using nanofibers containing EUD at concentrations 50, 250, 500 ppm as controller at 0 -312 time by a Spectrophotometry (UV) method Measured.    For every Nanofiber at 25 °C, 31 °C, 37 °C, and 43 °C, drug release studies were performed for 72 h. The nanofibers of EUD 500ppm, EUD 250 ppm and EUD 50ppm had the highest resistance to drug release, respectively. The results showed that EUD plays a very good role in controlling drug release at the nanofiber. Experimental data were done fitted better with the Sahlin-Peppas model. Kinetic studies have shown that due to the hydrophilic nature of EUD, both diffusion and swelling mechanisms contribute to the drug release process. Thermodynamic analysis showed that drug release leading to increased disorder (ΔS<0) is also an endothermic process (ΔH>0) and at all controlling concentrations is not spontaneous (ΔG>0). As the amount of the controller increases, activation energy increases.

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[1] K.  Zhang, Z.  Li, W.  Kang, N. Deng, J. Yan, J. Ju, Y. Liu, B. Cheng, Carbohydrate Polymers, 2017, 183, 62-69.

[2] A. Fuchs, A. Youssef, A. Seher, G. Hochleitner, P.D. Dalton, S. Hartmann, R.C. Brands, U.D.A. Müller-Richter, C. Linz, BMC Oral Health, 2019, 19, 28-38.

[3] M. Gorji, R. Bagherzadeh, H. Fashandi,   Electrospun Nanofibers, Elsevier, 2017, pp. 571-598.

[4] M. Eslamian, M. Khorrami, N. Yi, S. Majd, M.R. Abidian, Journal of Materials Chemistry B, 2019, 7, 224-232.

[5] D. W Dogo, H. Louis, N. I Iliya, A. U Ozioma, A. T Aderemi, B. Stware, Journal of Medicinal and Chemical Sciences, 2019, 2, 162-171.

[6] H. Mahmoudvand, M.F. Harandi, M. Shakibaie, M.R. Aflatoonian, N. ZiaAli, M.S. Makki, S. Jahanbakhsh, International Journal of Surgery, 2014, 12, 399-403.

[7] F.M. Ali, H.M. Ahmed, Chemical Methodologies, 2019, 3, 670-683.

[8] M. Joshi, Role of eudragit in targeted drug delivery, Int J Curr Pharm Res, 2013, 5, 58-62.

[9] İ.T. Değim, F. Tuğcu-Demiröz, S. Tamer-İlbasmış, F. Acartürk, Drug Delivery, 2008, 15, 259-265.

[10] K. Małolepsza-Jarmołowska, Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2006, 61, 780-782.

[11] R. Pignatello, C. Bucolo, P. Ferrara, A. Maltese, A. Puleo, G. Puglisi, European Journal of Pharmaceutical Sciences, 2008, 16, 53-61.

[12] M.A. Rahman, J. Ali, Indian Journal of Pharmaceutical Sciences, 2008, 70, 477-481.  

[13] V. Jamak, B. Ghosh, B. Desai, J. Khanam, Indian Journal of Pharmaceutical Sciences, 2006, 68, 556-561.

[14] A. George, P.A. Shah, P.S. Shrivastav, European Polymer Journal, 2018, 112, 722-735.

[15] Z. Heidari, M.  Mohebali, Z. Zarei, M. Aryayipour, M. Eshraghian, E. Kia, J. Abdi, A. Rakhshanpour, M. Rokni, Iranian Journal of Parasitology, 2011, 6, 19-25.                     

[16] A.M.S. Tahira, A. S. Bahjatb, A. Ahmad Mohammed. Annals of Medicine and Surgery, 2019, 47, 32–35.

[17] S.H. ArifUniversity, A. Mohamm.  International Journal of Surgery Case Reports, 2019, 60, 273–275.

[18] W.F. Hutchison, Studies on the hydatid worm, American Journal of Tropical Medicine and Hygiene. 1960, 9, 612-5.

[19] A. Navvabi, A. Homaei, S. Khademvatan, M.H. Khadem Ansari, M. Keshavarz, Biocatalysis and Agricultural Biotechnology, 2019, 22, 101-432.

[20] C.M. Creau, R.R. Codreanu, B. Mastalier, L.G. Popa, I. Cordoae, M. Beuran4, D.A. Steriu Ianulle5, S. Simion2, Chirurgia (Bucur), 2012, 107, 15-21.

[21] G. Singhvi, M. Singh, Int J Pharm Stud Res, 2011, 2, 77-84.

[22] H.K. Shaikh, R. Kshirsagar, S. Patil, World J. Pharm. Pharm. Sci., 2015, 4, 324-338.

[23] M.C.L.C. Freire, F. Alexandrino, H.R. Marcelino, P.H.d.S. Picciani, K.G.d.H.e. Silva, J. Genre, A.G.d. Oliveira, E.S.T.d. Egito, Materials, 2017, 10, 651-668.

[24] S. Dash, P.N. Murthy, L. Nath, P. Chowdhury, Acta Poloniae Pharmaceutica, 2010, 67, 217-223.

[25] B. Duan, X. Yuan, Y. Zhu, Y. Zhang, X. Li, Y. Zhang, K. Yao, European Polymer Journal, 2006, 42, 2013-2022.

[26] DM. Aragón, JE. Rosas, F. Martinez, Journal of Microencapsulation, 2013, 30, 218-224.