A green synthesis of functionalized thiazol-2(3H)-imine via a three-component tandem reaction in ionic liquid media

Shahvelayati, Ashraf Sadat; Hajiaghababaei, Leila; Panahi Sarmad, Akram

Document Type : Original Research Article

Authors

Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran

Abstract

In this research, an efficient synthesis toward 2-(2-((4-Methoxybenzoyl)imino)-4-(4-methoxyphenyl)thiazol-3(2H)-yl)-2-phenylacetic acid via a three-component tandem reaction using aroylisothiocyanate, phenyl glycine, and 4-methoxyphenacyl bromide in an ionic liquid (IL) has been described. 1-Methyl-3-pentylimidazolium bromide (IL) has been employed as a recyclable green solvent. The work-up procedure was fairly simple and the product did not require further purification. The influence of various reaction parameters such as solvent, temperature, and time was examined and among the various solvents such as ethanol, acetonitrile, n-hexane, water, and ionic liquid for synthesis of the final product, the best result was obtained in 1-methyl-3-pentylimidazolium bromide at 50oC for 1 hours.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

References

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Iranian chemical communication

A green synthesis of functionalized thiazol-2(3H)-imine via a three-component tandem reaction in ionic liquid media

References

References

Volume 5, Issue 3, pp. 237-363, Serial No. 16
July 2017
Pages 262-267

A green synthesis of functionalized thiazol-2(3H)-imine via a three-component tandem reaction in ionic liquid media

References

References

Volume 5, Issue 3, pp. 237-363, Serial No. 16July 2017Pages 262-267

Volume 5, Issue 3, pp. 237-363, Serial No. 16
July 2017
Pages 262-267