Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Synthesis, spectroscopic investigation and coductometry of a new hexadentate symmetric Schiff base ligand containing N2O2S2 donor atoms and related complexes with Cd(II), Zn(II), Co(II) and Mn (II) metal ions1331411891ENRezaGolbedaghiDepartment of Chemistry, Payame Noor University, 19395-4697, Tehran, Iran.EhsanAlavipourDepartment of Chemistry, Payame Noor University, 19395-4697, Tehran, Iran.Journal Article20150911In this paper, we report the synthesis and characterization of a new symmetric macroacyclic Schiff base ligand (H2L) and related complexes with different metals. (H2L) was synthesized by the one pot condensation reaction of 2-[2-(2-formyl phenoxy)ethoxy]benzaldehyde and 2-aminobenzenethiol in a 1:2 molar ratio. The acyclic Schiff base was characterized by IR, NMR spectroscopy and elemental analysis. Also, the resulting synthesized metal complexes in this work were characterized by elemental analysis, IR and molar conductivity in all cases and NMR spectroscopy for the case of Cd(II) complex. . The molar conductivities at 10-3 M concentration for the complexes in acetonitrile are in the range expected for their formulation as 1:2 electrolytes.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401A facile and efficient synthesis of Baclofen1421451893ENAliSaberiDepartment of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.Journal Article20150330γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesized by Claisen condensation of ethyl acetoacetate and p-chlorobenzaldehyde, formation of cyclic imide from β(p-chlorophenyl) glutaric acid and further Hoffmann rearrangement of β(p-chlorophenyl) glutarimid. Reagents used were inexpensive and commercially available. The overall yield of the reported strategy was 50% which is a good yield compare with other previous reports.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Isolation and identification of gallic acid from the elaeagnus angustifolia leaves and determination of total phenolic, flavonoids contents and investigation of antioxidant activity1461541892ENAbdolrezaAbriChemistry Department, Azarbaijan Shahid Madani University, 53714-161 Tabriz, IranMojganMalekiChemistry Department, Azarbaijan Shahid Madani University, 53714-161 Tabriz, IranJournal Article20150709Elaeagnus angustifolia has many potential applications in drugs, detergents, perfumes, herbal teas and show various biological and pharmacological activities, such as anti-inflammatory, antipyretic and other effective treatment of disease. Gallic acid (GA) and its derivative methyl gallate (MG) are well studied plant phenolics. They have exhibited anticancer effects in several cancer cell lines. In the present work, The E. angustifolia leaves were collected from the enclosure of Azerbaijan Shahid Madani University trees and were dried in the shade condition, were milled and extracted successively with n-hexane, ethyl acetate and methanol in a Soxhlet apparatus for 24 h. Further study on the methanol extract of this plant has resulted in the isolation of gallic acid. The structure of the compound was established by spectroscopic methods. Antioxidant properties of flavonoid and phenolic compoundes were measured.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401One-pot, four-component synthesis of fully substituted 1,3,4-oxadiazole derivatives from N-isocyaniminotriphenylphosphorane (Ph3PNNC), a primary amine, a carboxylic acid and cinnamaldehyde1551641894ENFatemehKalantariDepartment of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, IranAliRamazaniDepartment of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran0000-0003-3072-7924FatemehZeinali NasrabadiDepartment of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, IranJournal Article20150423The imine intermediate generated by the addition of primary amine to the cinnamaldehyde is trapped by the N-isocyaniminotriphenylphosphorane (Ph3PNNC) and a carboxylic acid, and leads to the formation of the corresponding iminophosphorane intermediate. The 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed under neutral conditions at room temperature. The fully substituted 1,3,4-oxadiazole derivatives were produced in high yields. The method offers a mild, simple, and efficient route for the preparation of fully substituted 1,3,4-oxadiazols. The structures of the products were deduced from their IR, 1H NMR, 13C NMR spectra, and mass spectrometry.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Synthesis and characterization of some polymer derivatives of carvacrol as drug delivery system1651741895ENMohammadGalehassadiChemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran.EbrahimRezaiiChemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran.Journal Article20150421Carvacrol is one of the main components of the EO of some Labiatae (Laminaceae) members like oregano, thyme and savory. Carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.We synthesized some silicon derivatives of carvacrol, and characterized them by standard methods. Then the monomer of dimethylvinylsilyl carvacrol was synthesized. Copolymer of this monomer and methacrylic acid (MAA) was synthesized with different ratios. And releases of these polymers as an drug delivery systems were investigated in the pH = 1 pH = 7.4.In this way , we stnthesized a new sily polymer with base of drug delivery system for a phytochemical compound.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Microwave-assisted synthesis of 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin and zinc derivative and study of their bacterial photoinactivation1751851935ENRahmatollahRahimiBioinorganic Chemistry Laboratory, Department of Chemistry, Iran University of Science and TechnologyFatemehFayyazBioinorganic Chemistry Laboratory, Department of Chemistry, Iran University of Science and TechnologyMehdiRassaDepartment of Biology, Faculty of Science, University of Guilan, Rasht, IranMahboubehRabbaniDepartment of Chemistry, Iran University of Science and Technology,Journal Article20150726In this study, 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) and its zinc porphyrin complex (ZnTNPP) were synthesized in situ using the microwave method and identified by UV-Vis, FT-IR and 1H NMR. The photostability and photodynamic antimicrobial activity (PACT) of these compounds were investigated on Pseudomonas aeruginosa and Bacillus subtilis under visible light irradiation. MIC, MBC and inhibition zones produced by these compounds were determined and the number of bacteria counted. The results indicated that both compounds have significant stability when illuminated for various illumination periods in nutrient broth media. Both compounds exhibited more effective activity against P. aeruginosa than B. subtilis in nutrient agar.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature1861972049ENVinodKambleOrganic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-440001 Maharashtra, India.SandeepAtkoreSchool of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Maharashtra, India.ParshuramPisalSchool of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Maharashtra, India.MunazzaSadafDepartment of Chemistry, Institute of Science, NagpurRenuka V.ThakreDepartment of Chemistry, Institute of Science, NagpurJournal Article20150307The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabutylammonium bromide (TBAB) and cesium carbonate in methanol. In the present method, the use of thermal condition is avoided. In addition, the advantages such as operational simplicity, economic viability, ecologically benign nature make this protocol a very efficient alternative to the literature methods.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Vanadium oxide supported on mesocellulous silica foams (MCF): An efficient and reusable catalyst for selective oxidation of sulfides1982061957ENZahraMohagheghianDepartment of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Iran.RaziehFazaeliDepartment of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Iran.HamidAliyanDepartment of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, IranJournal Article20150223A green, efficient and selective approach for the oxidation of sulfides to sulfoxides and sulfones with UHP at room temperature is reported. The reaction is performed in the presence of vanadia catalyst supported on mesocellular silica foam (MCF) with a V content ranging from 2% to 10% as heterogeneous and reusable catalyst. The structural and textural characterization of this catalyst were done using FTIR, X-ray diffraction, and N2 adsorption-desorption. This catalyst was found to be effective for selective oxidation of sulfides to sulfoxides and the 5.6% V/MCF catalyst showed the highest activity. It is noteworthy that the reaction tolerates oxidatively sensitive functional groups and the sulfur atom is selectively oxidized.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Dimethyl sulfide for 3-carboaldehyde pyridine displacement in a platinum(II) complex: Donor number effect2072132001ENAlirezaAkbariChemistry Department, Payame Noor University, 19395-4697 Tehran, Iran.Journal Article20150505The therrmodynamic parameters and equilibrium constant of displacement of dimethy sulfide by 3-carboaldehyde pyridine as N-donor ligand in cis-[Pt(4-MeC6H4)2(SMe2)2] complex have been measured using UV vis spectroscopy in acetone, dichloromethane and benzene at various temperatures (T=15-20 °C) and compared with previous my reported about similar reaction. ΔHo (KJ.mol-1) of the mentioned reaction in acetone has been 7.158 while obtained less in dichloromethane (4.109 ) and more in benzene(9.96). The entropy of the reaction has been obtained 86.86 J.mol-1.K-1 in acetone , while calculated less in CH2Cl2 (73.29 J.mol-1.K-1) and more in last solvent (97.40 J.mol-1.K-1). Also, the Gibbs energy, ΔG (J.mol-1), of the reaction obtained -18738.79, -17741.55 and -19043.06 respectively, with the same order. In all three solvents, the values of enthalpy and entropy change have been positive and decreased as the donor number of the solvents decreased.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401Sulfamic acid supported on cellulose as a biodegradable and recyclable heterogeneous catalyst for the synthesis of tetrahydrobenzo xanthene derivatives2142252102ENBatolZakerinasabDepartment of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, IranMohammad AliNasseriDepartment of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, IranHassanHassaniDepartment of Chemistry, Payam Noor University, Birjand, IranJournal Article20150522Cellulose bonded N-propyl diethylene tetra sulfamic acid (CBPDETSA) was successfully applied as a green and recyclable acidic catalyst for the synthesis of tetrahydrobenzo [a] xanthene-11-one as an important class of potentially bioactive compounds. The products are obtained by the coupling of 2-naphtol , cyclohexadione and aldehyde derivatives in good to high yields (70- 92%) under solvent-free conditions. The reactivity of different aromatic aldehydes was influenced by the nature and position of the substituents on the aromatic ring. The benzaldehyde derivatives having an electron-withdrawing substituent were highly reactive and gave the products in excellent yields. Also, the catalyst could be recovered by filtration and subjected to a second reaction process. The results show that the yield of product after five runs was only slightly reduced.Iranian chemical communication2423-49584Issue 2, pp. 133-235, Serial No. 1120160401One-pot three-component synthesis of dialkyl 3-(alkylamino)-1-aryl-1H-pyrazole-4,5-dicarboxylates using α-Fe2O3 nanoparticles and phenylisocyanate in solvent-free conditions2262352103ENBagherMohammadiDepartment of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.MaryamRahmaniDepartment of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.Journal Article20150705This work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1H-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-Fe2O3 nanoparticles. Eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily available catalysts are the main advantages of this method. In this work, phenylisocyanate and α-Fe2O3 nanoparticles used as a potent mixed catalyst for promoting the reaction and taking it in a special way to obtain the titled compounds in good to excellent yields. This reaction was not carried out without any of the components of this mixed catalyst. It means that for performance this reaction both of the mixed catalyst components is required.