Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001The anti cancer effects of Stachys Lavandulifolia extract2832901339ENMehdiForuzaniDepartment of Chemistry, Payame Nour University P.O. BOX 19395-3697Tehran, IranAbbas AliDehpourDepartment of Biology, Qaemshahr branch Islamic Azad University of Qaemshahr, IranMahlaMusaviDepartment of Chemistry, PayameNour University P.O. BOX19395-3697Tehran, IranJournal Article20140921Stachys is one of the largest genera in the flowering plant family. It is in the subfamily Lamioideae (Labiatae), spreading and growing in different parts of Iran. The purpose of this study was to investigate the chemical properties of Stachyslavandulifolia as well as the essence, ethanol and methanol extracts of this plant. It was collected from Chulus located in the West of Mazandaran Province. The ethanol and methanol extracts were provided using soxhlet and percolation. The extracts then were defatted and solvent removal performed in a subsequent process. The anticancer activity of extracts was also conducted using MTT assay method in this respect. The test results indicated that there is no significant effect on the inhibition of cell growth when the concentration of extracts is lower than 0.5 mg/ml clarifying that the more the increase in concentration, the more the reduction in growth inhibition.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Three component one-pot synthesis of 4H-benzo-[b]-pyran derivatives using [(diacetoxyiodo)benzene] (DIB) as a hypervalent iodine catalyst2913011340ENAmit S.WaghmareDepartment of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce, Pravaranagar, 413713 Maharashtra, IndiaShivaji S.PanditDepartment of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce, Pravaranagar, 413713 Maharashtra, IndiaJournal Article20141128The three components one pot synthesis of 2-amino-4H-benzo-[b] -pyran derivatives were obtained in good to excellent yields within short reaction time by condensing dimedone, aldehydes and malanonitrile or ethylcyanoacetate using a catalytic amount of (diacetoxyiodo)benzene as hypervalent iodine in aqueous ethanol under reflux conditions have been discussed. This aqua mediated Knoevenagel-cyclocondensation of various aromatic and hetero-aromatic aldehydes along with the aldehydes like aryl-sulphonyloxybenzaldehyde, aryl-carbonyloxybenzaldehyde also leads to the product under the same reaction conditions. High yields, shorter reaction times, one pot condensation, operational simplicity, easy work-up, purification of products by non-chromatographic methods are some additional features of the present protocol.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Unexpected one pot pseudo four-component reaction for the synthesis of (10E)-N-benzylidene-2-phenylH-imidazo [1,2-a]pyridin-3-amine derivatives under solvent-free conditions3023091369ENBagherMohammadiPayame Noor University of AbharMansoorShafieeyDepartment of Chemistry, Payame Noor university, P. O. Box 97, Abhar, Iran.HamedKazemiDepartment of Chemistry, Payame Noor university, P. O. Box 97, Abhar, Iran.Journal Article20141120This work described an efficient Pseudo four-component synthesis of (10E)-N-benzylidene-2-phenylH-imidazo[1,2-a]pyridin-3-amine derivatives from 2-aminopyridin, malononitrile and arylaldehydes in the presence of NaOH under solvent-free and conventional heating condition in good to excellent yields. A wide range of aromatic aldehydes would easily undergo condensations with 2-aminopyridin and malononitrile under solvent-free conditions in order to afford the desired products of good purity in excellent yields. For optimization of this reaction, the effect of NaOH amounts and use of other bases such as Et3N and Na2CO3 instead of NaOH and the efficacy of time and temperature to the reaction yields were studied. The use of simple and readily available starting materials, pharmacologically interest product, short reaction times, and applications in bioorganic and medicinal chemistry are the main advantages of this reaction.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Preparation of sterically congested 1,3,4-oxadiazole derivatives from N-isocyaniminotriphenylphosphorane, aromatic acids, cyclopentanone and primary amines3103221378ENHamidehJavanbaniUniversity of ZanjanAliRamazaniUNIVERSITY OF ZANJAN0000-0003-3072-7924Sang WooJooYeungnam UniversityYavarAhmadiYoung Researchers and Elite Clube, Marand Branch, Islamic Azad University0000-0002-4644-7794VahidAzizkhaniPayame Noor University0000-0001-5077-4571PegahAzimzadeh AsiabiNuclear Science and Technology Research InstituteJournal Article20141225Reactions of N-isocyaniminotriphenylphosphorane with cyclopentanone have been studied in the presence of aromatic carboxylic acids and primary amines, proceeds smoothly at room temperature under neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives by an intramolecular Aza-Wittig cyclization in CH2Cl2 in excellent yields. The structures of the products were deduced from their IR, Mass, ¹H NMR, and ¹³C NMR spectra. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed. The method offers a mild, simple, and efficient route for the preparation of fully substituted 1,3,4-oxadiazoles from cyclopentanone, primary amines, N-isocyaniminotriphenylphosphorane and aromatic carboxylic acids. Easy work-up, high yields and fairly mild reaction conditions make it a useful procedure in comparison to the modern synthetic methodologies.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Synthesis of some network polymers with siloxane units as a drug delivery system3233341403ENMohammadGalehassadiAzarbaijan Shahid Madani UniversitySamadOmidiAzarbaijam Shahid Madani UniversityJournal Article20141129New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by ter polymerization of methacrylic acid (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy) methylsilane (VBM) in the presence of some new cross-linking agents.<br />The monomers and polymers were characterized by FT-IR and 1H-NMR spectroscopy, and their thermal stability studied by DSC analysis. The hydrolysis of them were carried out in cellophane membrane dialysis bags containing aqueous buffer solution at 37 C. Detection of the hydrolysis product by UV spectroscopy method showed that attaching of siloxane units in these hydrogels modified this drug delivery system.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Efficient procedure for the synthesis of quinoline derivatives by NbCl5.PEG and NbCl5 in glycerol as green solvent3353471458ENBatolZakerinasabDepartment of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, IranMohammad AliNasseriDepartment of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, IranFatemeKamaliDepartment of Chemistry, College of Sciences, Birjand University, Birjand 97175-615, IranJournal Article20141013Quinolines, an important class of potentially bioactive compounds, have been synthesized by treatment of O-aminoarylketones and carbonyl compounds utilizing niobium (V) chloride / polyethylenglycole(NbCl5.PEG) and niobium(V)chloride (NbCl5) as available and inexpensive catalysts. The quinoline derivatives were prepared in glycerol, an excellent solvent in terms of environmental impact, with high yields (76-98%) and short reaction times (15- 90 min). Not only diketones but also ketones afforded the desired products in good to excellent yields. The reaction time of 2-amino-5-chlorobenzophenone and dicarbonyl compounds was longer than those of 2-aminobenzophenone. The reaction of cyclic diketones took place faster than open chain analogues. These reactions also proceeded with acetophenone derivatives. In these cases the reaction times are longer.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Determination of the absolute redox potential of methyldopa: experimental and simulation methodes3483551599ENRezaSamimi ShalamzariDepartment of Chemistry, Payame Noor University, PB BOX 19395-4697 Tehran, IranSiminMansouriDepartment of Chemistry, Payame Noor University, PB BOX 19395-4697 Tehran, IranAkramEghbaliDepartment of Chemistry, Payame Noor University, PB BOX 19395-4697 Tehran, IranJournal Article20140710The conditional formal potential, E°′of Methyldopa has been studied by cyclic voltammetry at the surface of activated glassy carbon electrode (AGCE) as the working electrode in different pH phosphate buffered solutions. The experimental Standard redox potential, E°′, of Methyldopa is obtained to be 0.72 mV versus SHE (Standard Hydrogen Electrode). E°′ values have also been calculated with the aid of density functional theory (DFT) method at B3LYP/6-311G Basis set in conjunction with a Polarizable Continuum Model (PCM). Innovative application of both Direct and indirect methods resulted in theoretical standard electrode potentials of the studied Methyldopa in the order of 0.68 and 0.74 mV, respectively. These results were found to be in excellent agreement with the experimental value in the order of 0.72 mV.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001[BMIm]BF4-LiCl as an effective catalytic system for the synthesis of dicoumarols3563661620ENSeyyedeh CobraAzimiIslamic Azad University, Rasht, IranKuroshRad-MoghadamDepartment of Chemistry, Guilan UniversityJournal Article20140913A homogeneous ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate doped with LiCl ([BMIm]BF4-LiCl) was found as catalyst solvents for the synthesis of dicoumarols by the condensation of 4-hydroxycoumarin and aldehyde at 80 ˚C. In this field, several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were rapidly changed to the corresponding derivatives in good to excellent yields. Application of this new homogeneous catalyst system offered the advantages of short reaction times, solvent-free conditions, high yields, and easy work-up procedure compared to the conventional methods of the syntheses. The ionic liquid can be recovered for the subsequent reactions and reused without any loss of efficiency.Iranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Green and efficient synthesis of trialkyl (E)-3-(3-Oxo-2-3,4-dihydro-2-(1H)-quinoxalinylidene)-prop-1-ene-1,2,3- tricarboxylates using K2CO3-PEG-400 as robust catalytic system3673731632ENMohammadPiltanDepartment of Chemistry, Faculty of Science, Sanandaj Branch, Islamic Azad University, Sanandaj, IranJournal Article20150307An efficient synthesis of trialkyl (E)-3-(3-Oxo-2-3,4-dihydro-2-(1H)-quinoxalinylidene)-prop-1-ene-1,2,3-tricarboxylate derivatives via a simple three-component reaction between benzene-1,2-diamines with dialkyl acetylenedicarboxylates in the presence of K2CO3-PEG catalytic system at 100 oC was reported. The desired products were obtained in excellent yields (88-92%). Various benzene-1,2-diamines, and dialkyl acetylendicarboxylate were used in the traditional method. <br />Quinolines are major classes of heterocyclic compounds, which have attracted considerable attention from chemists for their large broad biological activities and amazing physical properties. Furthermore, the synthesis of quinoxalines and their derivatives has received much attention from organic and medicinal chemists. As part of our current studies on the development of new routes to synthesize quinoxaline systems. The corresponding quinoxalines are useful building blocks for the construction of complex quinoxaline derivativesIranian chemical communication2423-49583Issue 4, pp. 283-387, Serial No. 920151001Synthesis of ZnO/Bi2O3 and SnO2/Bi2O3/Bi2O4 mixed oxides and their photocatalytic activity3743871678ENMaryamMovahediPayame Noor University,Isfahan, IRANAkramHosseinianDepartment of Engineering Science, University College of Engineering, University of Tehran,NasrinNazempourPayame Noor UniversityMohadesehRahimiPayame Noor UniversityHosseinSalavatiPayame Noor UniversityJournal Article20150215In the present work, ZnO/Bi2O3, SnO2/Bi2O3/Bi2O4 mixed oxide, Bi2O3 rod-like and SnO2 nanoparticle have been synthesized. The obtained samples were characterized by field emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD). The optical properties of samples were evaluated by UV-Vis spectrophotometer. The photocatalytic activity of samples was evaluated by decolorization of methylene blue (M.B.) solution. The Present work indicates the improving or hampering effect of Bi2O3 on the photocatalytic activity of ZnO/Bi2O3. The results show that the photocatalytic performance of ZnO/Bi2O3 which is higher than that of Bi2O3, SnO2, and SnO2/Bi2O3/Bi2O4 is related to the presence of the zinc oxide semiconductor. Furthermore, results indicated that the photoactivity of the SnO2/Bi2O3 system was not improved. The present work affirms the importanat position of energy levels and also the separation of photogenerated electron/hole pairs on the efficient photocatalytic performance.