2024-03-19T11:02:38Z
https://icc.journals.pnu.ac.ir/?_action=export&rf=summon&issue=310
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Synthesis, spectroscopic investigation and coductometry of a new hexadentate symmetric Schiff base ligand containing N2O2S2 donor atoms and related complexes with Cd(II), Zn(II), Co(II) and Mn (II) metal ions
Reza
Golbedaghi
Ehsan
Alavipour
In this paper, we report the synthesis and characterization of a new symmetric macroacyclic Schiff base ligand (H2L) and related complexes with different metals. (H2L) was synthesized by the one pot condensation reaction of 2-[2-(2-formyl phenoxy)ethoxy]benzaldehyde and 2-aminobenzenethiol in a 1:2 molar ratio. The acyclic Schiff base was characterized by IR, NMR spectroscopy and elemental analysis. Also, the resulting synthesized metal complexes in this work were characterized by elemental analysis, IR and molar conductivity in all cases and NMR spectroscopy for the case of Cd(II) complex. . The molar conductivities at 10-3 M concentration for the complexes in acetonitrile are in the range expected for their formulation as 1:2 electrolytes.
Schiff base
macroacyclic
symmetric
hexadentate
donor atoms
complex
2016
04
01
133
141
https://icc.journals.pnu.ac.ir/article_1891_0a81827b3d44332c0c7c4b0061ff6994.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
A facile and efficient synthesis of Baclofen
Ali
Saberi
γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesized by Claisen condensation of ethyl acetoacetate and p-chlorobenzaldehyde, formation of cyclic imide from β(p-chlorophenyl) glutaric acid and further Hoffmann rearrangement of β(p-chlorophenyl) glutarimid. Reagents used were inexpensive and commercially available. The overall yield of the reported strategy was 50% which is a good yield compare with other previous reports.
Baclofen
Synthesis
GABA receptor
γ-aminobutiric acid
2016
04
01
142
145
https://icc.journals.pnu.ac.ir/article_1893_96175da244578a5feacd5d1c623dee4f.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Isolation and identification of gallic acid from the elaeagnus angustifolia leaves and determination of total phenolic, flavonoids contents and investigation of antioxidant activity
Abdolreza
Abri
Mojgan
Maleki
Elaeagnus angustifolia has many potential applications in drugs, detergents, perfumes, herbal teas and show various biological and pharmacological activities, such as anti-inflammatory, antipyretic and other effective treatment of disease. Gallic acid (GA) and its derivative methyl gallate (MG) are well studied plant phenolics. They have exhibited anticancer effects in several cancer cell lines. In the present work, The E. angustifolia leaves were collected from the enclosure of Azerbaijan Shahid Madani University trees and were dried in the shade condition, were milled and extracted successively with n-hexane, ethyl acetate and methanol in a Soxhlet apparatus for 24 h. Further study on the methanol extract of this plant has resulted in the isolation of gallic acid. The structure of the compound was established by spectroscopic methods. Antioxidant properties of flavonoid and phenolic compoundes were measured.
Elaeagnus angustifolia
Gallic acid
isolation
soxhlet extractor
2016
04
01
146
154
https://icc.journals.pnu.ac.ir/article_1892_8396d285635b52f6ba3bd74ef1e0fc09.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
One-pot, four-component synthesis of fully substituted 1,3,4-oxadiazole derivatives from N-isocyaniminotriphenylphosphorane (Ph3PNNC), a primary amine, a carboxylic acid and cinnamaldehyde
Fatemeh
Kalantari
Ali
Ramazani
Fatemeh
Zeinali Nasrabadi
The imine intermediate generated by the addition of primary amine to the cinnamaldehyde is trapped by the N-isocyaniminotriphenylphosphorane (Ph3PNNC) and a carboxylic acid, and leads to the formation of the corresponding iminophosphorane intermediate. The 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed under neutral conditions at room temperature. The fully substituted 1,3,4-oxadiazole derivatives were produced in high yields. The method offers a mild, simple, and efficient route for the preparation of fully substituted 1,3,4-oxadiazols. The structures of the products were deduced from their IR, 1H NMR, 13C NMR spectra, and mass spectrometry.
N-isocyaniminotriphenylphosphorane
cinnamaldehyde
carboxylic acids
oxadiazole
aza-Wittig reaction
2016
04
01
155
164
https://icc.journals.pnu.ac.ir/article_1894_daf32f204423645a2c5e64a6f3459be8.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Synthesis and characterization of some polymer derivatives of carvacrol as drug delivery system
Mohammad
Galehassadi
Ebrahim
Rezaii
Carvacrol is one of the main components of the EO of some Labiatae (Laminaceae) members like oregano, thyme and savory. Carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.We synthesized some silicon derivatives of carvacrol, and characterized them by standard methods. Then the monomer of dimethylvinylsilyl carvacrol was synthesized. Copolymer of this monomer and methacrylic acid (MAA) was synthesized with different ratios. And releases of these polymers as an drug delivery systems were investigated in the pH = 1 pH = 7.4.In this way , we stnthesized a new sily polymer with base of drug delivery system for a phytochemical compound.
carvacrol
oregano
silyl ethers
copolymer
drug delivery
2016
04
01
165
174
https://icc.journals.pnu.ac.ir/article_1895_df8a200fd25a1544e349a629471af01d.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Microwave-assisted synthesis of 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin and zinc derivative and study of their bacterial photoinactivation
Rahmatollah
Rahimi
Fatemeh
Fayyaz
Mehdi
Rassa
Mahboubeh
Rabbani
In this study, 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) and its zinc porphyrin complex (ZnTNPP) were synthesized in situ using the microwave method and identified by UV-Vis, FT-IR and 1H NMR. The photostability and photodynamic antimicrobial activity (PACT) of these compounds were investigated on Pseudomonas aeruginosa and Bacillus subtilis under visible light irradiation. MIC, MBC and inhibition zones produced by these compounds were determined and the number of bacteria counted. The results indicated that both compounds have significant stability when illuminated for various illumination periods in nutrient broth media. Both compounds exhibited more effective activity against P. aeruginosa than B. subtilis in nutrient agar.
Antimicrobial activity
Bacillus subtilis
photoinactivation
pseudomonas aeruginosa
TNPP
2016
04
01
175
185
https://icc.journals.pnu.ac.ir/article_1935_cb24098fd616dfbce9f734c2f2b19b67.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature
Vinod
Kamble
Sandeep
Atkore
Parshuram
Pisal
Munazza
Sadaf
Renuka
Thakre
The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabutylammonium bromide (TBAB) and cesium carbonate in methanol. In the present method, the use of thermal condition is avoided. In addition, the advantages such as operational simplicity, economic viability, ecologically benign nature make this protocol a very efficient alternative to the literature methods.
aldehydes
malonitrile
thiophenol
substituted pyridines
tetrabutylammonium bromide
Cesium carbonate
2016
04
01
186
197
https://icc.journals.pnu.ac.ir/article_2049_0e4053c5d645a1575e77fa11481e6ea0.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Vanadium oxide supported on mesocellulous silica foams (MCF): An efficient and reusable catalyst for selective oxidation of sulfides
Zahra
Mohagheghian
Razieh
Fazaeli
Hamid
Aliyan
A green, efficient and selective approach for the oxidation of sulfides to sulfoxides and sulfones with UHP at room temperature is reported. The reaction is performed in the presence of vanadia catalyst supported on mesocellular silica foam (MCF) with a V content ranging from 2% to 10% as heterogeneous and reusable catalyst. The structural and textural characterization of this catalyst were done using FTIR, X-ray diffraction, and N2 adsorption-desorption. This catalyst was found to be effective for selective oxidation of sulfides to sulfoxides and the 5.6% V/MCF catalyst showed the highest activity. It is noteworthy that the reaction tolerates oxidatively sensitive functional groups and the sulfur atom is selectively oxidized.
Supported vanadia catalyst
impregnation method
oxidation of sulfides
mesocellular silica foams
2016
04
01
198
206
https://icc.journals.pnu.ac.ir/article_1957_2fe3231b6170660af81df77afe206fa5.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Dimethyl sulfide for 3-carboaldehyde pyridine displacement in a platinum(II) complex: Donor number effect
Alireza
Akbari
The therrmodynamic parameters and equilibrium constant of displacement of dimethy sulfide by 3-carboaldehyde pyridine as N-donor ligand in cis-[Pt(4-MeC6H4)2(SMe2)2] complex have been measured using UV vis spectroscopy in acetone, dichloromethane and benzene at various temperatures (T=15-20 °C) and compared with previous my reported about similar reaction. ΔHo (KJ.mol-1) of the mentioned reaction in acetone has been 7.158 while obtained less in dichloromethane (4.109 ) and more in benzene(9.96). The entropy of the reaction has been obtained 86.86 J.mol-1.K-1 in acetone , while calculated less in CH2Cl2 (73.29 J.mol-1.K-1) and more in last solvent (97.40 J.mol-1.K-1). Also, the Gibbs energy, ΔG (J.mol-1), of the reaction obtained -18738.79, -17741.55 and -19043.06 respectively, with the same order. In all three solvents, the values of enthalpy and entropy change have been positive and decreased as the donor number of the solvents decreased.
platinum
thermodynamic
3- carboaldahyde pyridine
donor number
2016
04
01
207
213
https://icc.journals.pnu.ac.ir/article_2001_36807c527280429b1c6aeb30f590ccb4.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
Sulfamic acid supported on cellulose as a biodegradable and recyclable heterogeneous catalyst for the synthesis of tetrahydrobenzo xanthene derivatives
Batol
Zakerinasab
Mohammad Ali
Nasseri
Hassan
Hassani
Cellulose bonded N-propyl diethylene tetra sulfamic acid (CBPDETSA) was successfully applied as a green and recyclable acidic catalyst for the synthesis of tetrahydrobenzo [a] xanthene-11-one as an important class of potentially bioactive compounds. The products are obtained by the coupling of 2-naphtol , cyclohexadione and aldehyde derivatives in good to high yields (70- 92%) under solvent-free conditions. The reactivity of different aromatic aldehydes was influenced by the nature and position of the substituents on the aromatic ring. The benzaldehyde derivatives having an electron-withdrawing substituent were highly reactive and gave the products in excellent yields. Also, the catalyst could be recovered by filtration and subjected to a second reaction process. The results show that the yield of product after five runs was only slightly reduced.
Heterogeneous catalyst
cellulose
xanthene
solvent-free
CBPDETSA
2016
04
01
214
225
https://icc.journals.pnu.ac.ir/article_2102_58ad90fe196b69981d9197edba596210.pdf
Iranian chemical communication
2423-4958
2423-4958
2016
4
Issue 2, pp. 133-235, Serial No. 11
One-pot three-component synthesis of dialkyl 3-(alkylamino)-1-aryl-1H-pyrazole-4,5-dicarboxylates using α-Fe2O3 nanoparticles and phenylisocyanate in solvent-free conditions
Bagher
Mohammadi
Maryam
Rahmani
This work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1H-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-Fe2O3 nanoparticles. Eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily available catalysts are the main advantages of this method. In this work, phenylisocyanate and α-Fe2O3 nanoparticles used as a potent mixed catalyst for promoting the reaction and taking it in a special way to obtain the titled compounds in good to excellent yields. This reaction was not carried out without any of the components of this mixed catalyst. It means that for performance this reaction both of the mixed catalyst components is required.
pyrazole
α-Fe2O3
phenylisocyanate
nanocatalyst
solvent-free
2016
04
01
226
235
https://icc.journals.pnu.ac.ir/article_2103_91868cf917a797da7fdf4cb5bc4eea88.pdf