TY - JOUR ID - 3892 TI - Application of ZrO2–SO3H as highly efficient recyclable nano-catalyst for the green synthesis of fluoroquinolones as potential antibacterial JO - Iranian chemical communication JA - ICC LA - en SN - 2423-4958 AU - Nakhaei, Ahmad AU - Davoodnia, Abolghasem AU - Yadegarian, Sepideh AD - Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Iran AD - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran Y1 - 2019 PY - 2019 VL - 7 IS - Issue 4. pp. 230-306, Serial No. 25 SP - 239 EP - 250 KW - Fluoroquinolone derivatives KW - antibacterial KW - fast and green synthesis KW - zirconia sulfuric acid (ZrSA) DO - 10.30473/icc.2018.3892 N2 - Various antibacterial fluoroquinolone compounds were prepared by the direct amination of 7-halo-6- fluoroquinolone-3-carboxylic acids with variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine using Zirconia Sulfuric Acid (ZrSA) nanoparticle, as a catalyst in refluxing water. The results showed that ZrSA exhibited high catalytic activity towards the synthesis of fluoroquinolone derivatives, with the desired products being formed in high yields. Furthermore, the catalyst was recyclable and could be reused at least three times without any discernible loss in its catalytic activity. Overall, this new catalytic method for the synthesis of fluoroquinolone derivatives provides rapid access to the desired compounds in refluxing water following a simple work‐up procedure, and avoids the use of harmful organic solvents. This method therefore represents a significant improvement over the methods currently available for the synthesis of fluoroquinolone derivatives. UR - https://icc.journals.pnu.ac.ir/article_3892.html L1 - https://icc.journals.pnu.ac.ir/article_3892_be9b2d6d00717d03148f30397ee40b08.pdf ER -