TY - JOUR ID - 3007 TI - One-pot, organocatalytic synthesis of spirooxindoles using citric acid in aqueous media JO - Iranian chemical communication JA - ICC LA - en SN - 2423-4958 AU - Karimi-Jaberi, Zahed AU - Fereydoonnezhad, Abdolhossein AD - Firoozabad Branch, Islamic Azad University Y1 - 2017 PY - 2017 VL - 5 IS - Issue 4, pp. 364-493, Serial No. 17 SP - 407 EP - 416 KW - isatin KW - malononitrile KW - indole KW - spirooxindoles KW - citric acid DO - N2 - Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications.The development of multicomponent reactions designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. in this Manuscript, a facile and efficient multicomponent synthesis of functionalized spirooxindoles has been described through the reaction of isatin, malononitrile or ethyl cyanoacetate, and CH- acids (1,3-dicarbonyl compounds) in the presence of catalytic amount of citric acid in excellent yields with short reaction times in aqueous ethanol. Also citric acid catalyzed synthesis of 3,3-diindolyl oxindoles by the condensation of isatin with substituted indoles. UR - https://icc.journals.pnu.ac.ir/article_3007.html L1 - https://icc.journals.pnu.ac.ir/article_3007_2e75351bb2f24b8e0e2072815dc00c74.pdf ER -