Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Synthesis, spectroscopic investigation and coductometry of a new hexadentate symmetric Schiff base ligand containing N2O2S2 donor atoms and related complexes with Cd(II), Zn(II), Co(II) and Mn (II) metal ions
133
141
EN
Reza
Golbedaghi
Department of Chemistry, Payame Noor University, 19395-4697, Tehran, Iran.
golbedaghi82@gmail.com
Ehsan
Alavipour
Department of Chemistry, Payame Noor University, 19395-4697, Tehran, Iran.
ehsan.alavai1987@gmail.com
In this paper, we report the synthesis and characterization of a new symmetric macroacyclic Schiff base ligand (H2L) and related complexes with different metals. (H2L) was synthesized by the one pot condensation reaction of 2-[2-(2-formyl phenoxy)ethoxy]benzaldehyde and 2-aminobenzenethiol in a 1:2 molar ratio. The acyclic Schiff base was characterized by IR, NMR spectroscopy and elemental analysis. Also, the resulting synthesized metal complexes in this work were characterized by elemental analysis, IR and molar conductivity in all cases and NMR spectroscopy for the case of Cd(II) complex. . The molar conductivities at 10-3 M concentration for the complexes in acetonitrile are in the range expected for their formulation as 1:2 electrolytes.
Schiff base,macroacyclic,symmetric,hexadentate,donor atoms,complex
https://icc.journals.pnu.ac.ir/article_1891.html
https://icc.journals.pnu.ac.ir/article_1891_0a81827b3d44332c0c7c4b0061ff6994.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
A facile and efficient synthesis of Baclofen
142
145
EN
Ali
Saberi
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.
γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesized by Claisen condensation of ethyl acetoacetate and p-chlorobenzaldehyde, formation of cyclic imide from β(p-chlorophenyl) glutaric acid and further Hoffmann rearrangement of β(p-chlorophenyl) glutarimid. Reagents used were inexpensive and commercially available. The overall yield of the reported strategy was 50% which is a good yield compare with other previous reports.
Baclofen,Synthesis,GABA receptor,γ-aminobutiric acid
https://icc.journals.pnu.ac.ir/article_1893.html
https://icc.journals.pnu.ac.ir/article_1893_96175da244578a5feacd5d1c623dee4f.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Isolation and identification of gallic acid from the elaeagnus angustifolia leaves and determination of total phenolic, flavonoids contents and investigation of antioxidant activity
146
154
EN
Abdolreza
Abri
Chemistry Department, Azarbaijan Shahid Madani University, 53714-161 Tabriz, Iran
ar.abri@azaruniv.ac.ir
Mojgan
Maleki
Chemistry Department, Azarbaijan Shahid Madani University, 53714-161 Tabriz, Iran
m.phytochemistry@yahoo.com
Elaeagnus angustifolia has many potential applications in drugs, detergents, perfumes, herbal teas and show various biological and pharmacological activities, such as anti-inflammatory, antipyretic and other effective treatment of disease. Gallic acid (GA) and its derivative methyl gallate (MG) are well studied plant phenolics. They have exhibited anticancer effects in several cancer cell lines. In the present work, The E. angustifolia leaves were collected from the enclosure of Azerbaijan Shahid Madani University trees and were dried in the shade condition, were milled and extracted successively with n-hexane, ethyl acetate and methanol in a Soxhlet apparatus for 24 h. Further study on the methanol extract of this plant has resulted in the isolation of gallic acid. The structure of the compound was established by spectroscopic methods. Antioxidant properties of flavonoid and phenolic compoundes were measured.
Elaeagnus angustifolia,Gallic acid,isolation,soxhlet extractor
https://icc.journals.pnu.ac.ir/article_1892.html
https://icc.journals.pnu.ac.ir/article_1892_8396d285635b52f6ba3bd74ef1e0fc09.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
One-pot, four-component synthesis of fully substituted 1,3,4-oxadiazole derivatives from N-isocyaniminotriphenylphosphorane (Ph3PNNC), a primary amine, a carboxylic acid and cinnamaldehyde
155
164
EN
Fatemeh
Kalantari
Department of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran
kalantari.2003@gmail.com
Ali
Ramazani
0000-0003-3072-7924
Department of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran
aliramazani@gmail.com
Fatemeh
Zeinali Nasrabadi
Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran
f_pzeinali@yahoo.com
The imine intermediate generated by the addition of primary amine to the cinnamaldehyde is trapped by the N-isocyaniminotriphenylphosphorane (Ph3PNNC) and a carboxylic acid, and leads to the formation of the corresponding iminophosphorane intermediate. The 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed under neutral conditions at room temperature. The fully substituted 1,3,4-oxadiazole derivatives were produced in high yields. The method offers a mild, simple, and efficient route for the preparation of fully substituted 1,3,4-oxadiazols. The structures of the products were deduced from their IR, 1H NMR, 13C NMR spectra, and mass spectrometry.
N-isocyaniminotriphenylphosphorane,cinnamaldehyde,carboxylic acids,oxadiazole,aza-Wittig reaction
https://icc.journals.pnu.ac.ir/article_1894.html
https://icc.journals.pnu.ac.ir/article_1894_daf32f204423645a2c5e64a6f3459be8.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Synthesis and characterization of some polymer derivatives of carvacrol as drug delivery system
165
174
EN
Mohammad
Galehassadi
Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran.
mgalehassadi@yahoo.com
Ebrahim
Rezaii
Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran.
ebrahimrezayii@gmail.com
Carvacrol is one of the main components of the EO of some Labiatae (Laminaceae) members like oregano, thyme and savory. Carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.We synthesized some silicon derivatives of carvacrol, and characterized them by standard methods. Then the monomer of dimethylvinylsilyl carvacrol was synthesized. Copolymer of this monomer and methacrylic acid (MAA) was synthesized with different ratios. And releases of these polymers as an drug delivery systems were investigated in the pH = 1 pH = 7.4.In this way , we stnthesized a new sily polymer with base of drug delivery system for a phytochemical compound.
carvacrol,oregano,silyl ethers,copolymer,drug delivery
https://icc.journals.pnu.ac.ir/article_1895.html
https://icc.journals.pnu.ac.ir/article_1895_df8a200fd25a1544e349a629471af01d.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Microwave-assisted synthesis of 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin and zinc derivative and study of their bacterial photoinactivation
175
185
EN
Rahmatollah
Rahimi
Bioinorganic Chemistry Laboratory, Department of Chemistry, Iran University of Science and Technology
rahmatollah.rahimi93@gmail.com
Fatemeh
Fayyaz
Bioinorganic Chemistry Laboratory, Department of Chemistry, Iran University of Science and Technology
f.fayyaz@yahoo.com
Mehdi
Rassa
Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran
rassa9@yahoo.com
Mahboubeh
Rabbani
Department of Chemistry, Iran University of Science and Technology,
m_rabani@iust.ac.ir
In this study, 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) and its zinc porphyrin complex (ZnTNPP) were synthesized in situ using the microwave method and identified by UV-Vis, FT-IR and 1H NMR. The photostability and photodynamic antimicrobial activity (PACT) of these compounds were investigated on Pseudomonas aeruginosa and Bacillus subtilis under visible light irradiation. MIC, MBC and inhibition zones produced by these compounds were determined and the number of bacteria counted. The results indicated that both compounds have significant stability when illuminated for various illumination periods in nutrient broth media. Both compounds exhibited more effective activity against P. aeruginosa than B. subtilis in nutrient agar.
Antimicrobial activity,Bacillus subtilis,photoinactivation,pseudomonas aeruginosa,TNPP
https://icc.journals.pnu.ac.ir/article_1935.html
https://icc.journals.pnu.ac.ir/article_1935_cb24098fd616dfbce9f734c2f2b19b67.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature
186
197
EN
Vinod
Kamble
Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-440001 Maharashtra, India.
vtkdh1@gmail.com
Sandeep
Atkore
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Maharashtra, India.
sandeepat@rediffmail.com
Parshuram
Pisal
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Maharashtra, India.
parshuramm@rediffmail.com
Munazza
Sadaf
Department of Chemistry, Institute of Science, Nagpur
munazzasadaf@gmail.com
Renuka
V.
Thakre
Department of Chemistry, Institute of Science, Nagpur
renu_t@rediffmail.com
The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabutylammonium bromide (TBAB) and cesium carbonate in methanol. In the present method, the use of thermal condition is avoided. In addition, the advantages such as operational simplicity, economic viability, ecologically benign nature make this protocol a very efficient alternative to the literature methods.
aldehydes,malonitrile,thiophenol,substituted pyridines,tetrabutylammonium bromide,Cesium carbonate
https://icc.journals.pnu.ac.ir/article_2049.html
https://icc.journals.pnu.ac.ir/article_2049_0e4053c5d645a1575e77fa11481e6ea0.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Vanadium oxide supported on mesocellulous silica foams (MCF): An efficient and reusable catalyst for selective oxidation of sulfides
198
206
EN
Zahra
Mohagheghian
Department of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Iran.
yasbeheshti@gmail.com
Razieh
Fazaeli
Department of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Iran.
raziehfazaeli@yahoo.com
Hamid
Aliyan
Department of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Iran
aliyan@iaush.ac.ir
A green, efficient and selective approach for the oxidation of sulfides to sulfoxides and sulfones with UHP at room temperature is reported. The reaction is performed in the presence of vanadia catalyst supported on mesocellular silica foam (MCF) with a V content ranging from 2% to 10% as heterogeneous and reusable catalyst. The structural and textural characterization of this catalyst were done using FTIR, X-ray diffraction, and N2 adsorption-desorption. This catalyst was found to be effective for selective oxidation of sulfides to sulfoxides and the 5.6% V/MCF catalyst showed the highest activity. It is noteworthy that the reaction tolerates oxidatively sensitive functional groups and the sulfur atom is selectively oxidized.
Supported vanadia catalyst,impregnation method,oxidation of sulfides,mesocellular silica foams
https://icc.journals.pnu.ac.ir/article_1957.html
https://icc.journals.pnu.ac.ir/article_1957_2fe3231b6170660af81df77afe206fa5.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Dimethyl sulfide for 3-carboaldehyde pyridine displacement in a platinum(II) complex: Donor number effect
207
213
EN
Alireza
Akbari
Chemistry Department, Payame Noor University, 19395-4697 Tehran, Iran.
ali_r_akbari@yahoo.com
The therrmodynamic parameters and equilibrium constant of displacement of dimethy sulfide by 3-carboaldehyde pyridine as N-donor ligand in cis-[Pt(4-MeC6H4)2(SMe2)2] complex have been measured using UV vis spectroscopy in acetone, dichloromethane and benzene at various temperatures (T=15-20 °C) and compared with previous my reported about similar reaction. ΔHo (KJ.mol-1) of the mentioned reaction in acetone has been 7.158 while obtained less in dichloromethane (4.109 ) and more in benzene(9.96). The entropy of the reaction has been obtained 86.86 J.mol-1.K-1 in acetone , while calculated less in CH2Cl2 (73.29 J.mol-1.K-1) and more in last solvent (97.40 J.mol-1.K-1). Also, the Gibbs energy, ΔG (J.mol-1), of the reaction obtained -18738.79, -17741.55 and -19043.06 respectively, with the same order. In all three solvents, the values of enthalpy and entropy change have been positive and decreased as the donor number of the solvents decreased.
platinum,thermodynamic,3- carboaldahyde pyridine,donor number
https://icc.journals.pnu.ac.ir/article_2001.html
https://icc.journals.pnu.ac.ir/article_2001_36807c527280429b1c6aeb30f590ccb4.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
Sulfamic acid supported on cellulose as a biodegradable and recyclable heterogeneous catalyst for the synthesis of tetrahydrobenzo xanthene derivatives
214
225
EN
Batol
Zakerinasab
Department of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, Iran
bzakerinasab@birjand.ac.ir
Mohammad Ali
Nasseri
Department of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, Iran
manasri@birjand.ac.ir
Hassan
Hassani
Department of Chemistry, Payam Noor University, Birjand, Iran
hassaniir@yahoo.com
Cellulose bonded N-propyl diethylene tetra sulfamic acid (CBPDETSA) was successfully applied as a green and recyclable acidic catalyst for the synthesis of tetrahydrobenzo [a] xanthene-11-one as an important class of potentially bioactive compounds. The products are obtained by the coupling of 2-naphtol , cyclohexadione and aldehyde derivatives in good to high yields (70- 92%) under solvent-free conditions. The reactivity of different aromatic aldehydes was influenced by the nature and position of the substituents on the aromatic ring. The benzaldehyde derivatives having an electron-withdrawing substituent were highly reactive and gave the products in excellent yields. Also, the catalyst could be recovered by filtration and subjected to a second reaction process. The results show that the yield of product after five runs was only slightly reduced.
Heterogeneous catalyst,cellulose,xanthene,solvent-free,CBPDETSA
https://icc.journals.pnu.ac.ir/article_2102.html
https://icc.journals.pnu.ac.ir/article_2102_58ad90fe196b69981d9197edba596210.pdf
Iranian chemical communication
2423-4958
2345-4806
4
Issue 2, pp. 133-235, Serial No. 11
2016
04
01
One-pot three-component synthesis of dialkyl 3-(alkylamino)-1-aryl-1H-pyrazole-4,5-dicarboxylates using α-Fe2O3 nanoparticles and phenylisocyanate in solvent-free conditions
226
235
EN
Bagher
Mohammadi
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.
bagher.mohammadi@yahoo.com
Maryam
Rahmani
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.
maryamrahmani381@yahoo.com
This work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1H-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-Fe2O3 nanoparticles. Eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily available catalysts are the main advantages of this method. In this work, phenylisocyanate and α-Fe2O3 nanoparticles used as a potent mixed catalyst for promoting the reaction and taking it in a special way to obtain the titled compounds in good to excellent yields. This reaction was not carried out without any of the components of this mixed catalyst. It means that for performance this reaction both of the mixed catalyst components is required.
pyrazole,α-Fe2O3,phenylisocyanate,nanocatalyst,solvent-free
https://icc.journals.pnu.ac.ir/article_2103.html
https://icc.journals.pnu.ac.ir/article_2103_91868cf917a797da7fdf4cb5bc4eea88.pdf