%0 Journal Article %T A new facile route to synthesize thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives %J Iranian chemical communication %I %Z 2423-4958 %A Soleimany, Mehdi %A Lari, Jalil %A Vahedi, Hooshang %A Imanpour, Morteza %D 2015 %\ 04/01/2015 %V 3 %N Issue 2, pp. 72-147, Serial No. 7 %P 114-120 %! A new facile route to synthesize thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives %K Thieno[3 %K 2-e][1 %K 2 %K 4]triazolo[4 %K 3-c]pyrimidines heterocyclization acetic anhydride air oxidation %R %X A new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air oxidation. The products were obtained in high yield with an easy work-up in simple reaction along with the puriļ¬cation of products by non-chromatographic method. This general synthetic procedure can be extended to the preparation of a wide variety of isomeric triazoles using 2-amino thiophene-3-carboxamide bifunctional derivatives. %U https://icc.journals.pnu.ac.ir/article_990_64c0478c874aeb47e50c95b79b0dacdb.pdf