Melamine trisulfonic acid as a highly efficient catalyst for the synthesis of polyhydroquinolines under solvent-free conditions

Zare, Abdolkarim; Dashtizadeh, Maryam; Merajoddin, Maria

Document Type : Original Research Article

Authors

¹ Department of Chemistry, Payame Noor University of Bushehr, Bushehr, Iran

² Department of Chemistry, Payame Noor University, PO BOX 19395-4697, Tehran, Iran

Abstract

A highly efficient, simple and clean solvent-free protocol for the synthesis of polyhydroquinolines is described. The one-pot multi-component condensation reaction between arylaldehydes, dimedone (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammonium acetate in the presence of catalytic amount of (2.5 mol%) melamine trisulfonic acid (MTSA) as a recyclable, green and attractive sulfonic acid-containing catalyst at 60 °C affords the title compounds in high yields (83-98%) and short reaction times (3-30 min). The advantages of this method are efficiency, generality, high yield, short reaction time, cleaner reaction profile, simplicity, recyclability of the catalyst, ease of product isolation, and good compliance with the green chemistry protocols.

Graphical Abstract

Keywords

Main Subjects

Organic chemistry

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Iranian chemical communication

Melamine trisulfonic acid as a highly efficient catalyst for the synthesis of polyhydroquinolines under solvent-free conditions

References

References

Volume 3, Issue 3, pp. 180-282,Serial No. 8
July 2015
Pages 208-217

Melamine trisulfonic acid as a highly efficient catalyst for the synthesis of polyhydroquinolines under solvent-free conditions

References

References

Volume 3, Issue 3, pp. 180-282,Serial No. 8July 2015Pages 208-217

Volume 3, Issue 3, pp. 180-282,Serial No. 8
July 2015
Pages 208-217